Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
This Phase 1 clinical trial evaluates the combination of nintedanib and azacitidine in adults with HOX gene overexpression acute myeloid leu…
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Tomivosertib in Relapsed or Refractory Acute Myeloid Leukemia (AML) [Phase 1]
This entry reports a Phase 1 trial of Tomivosertib in relapsed or refractory acute myeloid leukemia, sponsored by Northwestern University; t…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: IS-free Treg HaploHCT [Phase 1]
A Phase 1 clinical trial at Dana-Farber Cancer Institute evaluating an IS-free regulatory T cell haploidentical hematopoietic cell transplan…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors [Phase 1]
Phase 1 pediatric trial evaluating alpha/beta CD19+ depleted haploidentical transplantation in combination with Zoledronic acid (Zometa) for…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS [NA]
Clinical trial investigating whole genome sequencing (ChromoSeq) as an adjunct to conventional genomic profiling in acute myeloid leukemia a…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome [Phase 1, Phase 2]
This trial evaluates a targeted radiopharmaceutical (211At-BC8-B10) followed by an allogeneic donor stem cell transplant for relapsed or ref…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant [Phase 2]
Phase 2 clinical trial evaluating naive T cell depletion to prevent chronic graft-versus-host disease in children and young adults receiving…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating interferon-γ in combination with donor leukocyte infusion for relapsed acute myeloid leukemia and myelodys…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating venetoclax-augmented treosulfan-based reduced-intensity conditioning before allogeneic stem cell transplan…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant [Phase 2]
A Phase 2 clinical trial from University of Alabama at Birmingham evaluating a two-step anti-thymocyte globulin regimen to prevent acute gra…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes
This clinical trial update concerns a Brescia-based study using next-generation sequencing to investigate familial acute myeloid leukemia an…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: A Phase 1B Investigator Initiated Study of Safety and Tolerability of Dexamethasone (D) in Combination With Venetoclax-based Low-Intensity Therapy (LIT) in Treatment-Naïve Acute Myeloid Leukemia (AML): DLIT-AML [Phase 1]
Phase 1B investigator-initiated study evaluating safety and tolerability of dexamethasone in combination with venetoclax-based low-intensity…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The document announces a new clinical trial called HALO-SCT, assessing high-altitude observation in stem cell transplantation. It is current…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Prospective Non-interventional Study of Adult Patients With Acute Myeloid Leukemia (AML)
Prospective non-interventional study enrolling adults with acute myeloid leukemia to observe real-world treatment patterns and outcomes.
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: AB8939 in Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial of AB8939 for relapsed or refractory acute myeloid leukemia is currently recruiting. The study also references my…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: CD123+CLL-1 CAR-T Sequential Infusion With CD7 CAR-T and Bridging to Allo-HSCT for Relapsed/Refractory Acute Myeloid Leukemia [EARLY_Phase 1]
This early-phase clinical trial update describes sequential infusion of CD123+CLL-1 CAR-T cells with a CD7 CAR-T and bridging to allogeneic …
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: The Efficacy of Triple Regimen in Newly Diagnosed AML Patients With FLT3 Mutation [Phase 1, Phase 2]
A Phase 1/Phase 2 study is evaluating a triple regimen for newly diagnosed acute myeloid leukemia with FLT3 mutation. Recruitment is ongoing…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic Syndrome [Phase 1, Phase 2]
MP0533 is being studied in patients with acute myeloid leukemia or myelodysplastic syndrome in a Phase 1/2 trial that is currently recruitin…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: CLL-1 CAR-NK Cells for Relapsed/Refractory AML [Phase 1]
This clinical trial update reports a Phase 1 study evaluating CAR-NK cells targeting CLL-1 for relapsed or refractory acute myeloid leukemia…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: A Study of A-CAR028 Treatment in Subjects With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
A-CAR028 is being studied in a Phase 1 trial for relapsed or refractory acute myeloid leukemia and the study is currently recruiting. The do…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Study of Liposomal Annamycin in Combination With Cytarabine for the Treatment of Subjects With Acute Myeloid Leukemia (AML) [Phase 1, Phase 2]
This entry summarizes a completed Phase 1/2 clinical trial evaluating liposomal annamycin in combination with cytarabine for acute myeloid l…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies [EARLY_Phase 1]
An early-phase trial evaluating Darzalex Faspro (daratumumab and hyaluronidase-fihj) given before desensitization and allogeneic stem cell t…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: A Study of BL-M11D1 in Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
A Phase 1 clinical trial evaluating BL-M11D1 for relapsed/refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Study of Lisaftoclax (APG-2575) Single Agent and Combination With Therapy in Patients Relapsed/Refractory AML [Phase 1, Phase 2]
This clinical trial update reports that Lisaftoclax (APG-2575) is being studied as a single agent and in combination for relapsed/refractory…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Single Arm Study of Post-transplant Azacitidine and Chidamide for Prevention of Acute Myelogenous Leukemia Relapse [Phase 1, Phase 2]
A single-arm Phase 1/2 clinical trial evaluating post-transplant azacitidine plus chidamide to prevent relapse in acute myeloid leukemia; re…