Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia [Phase 1, Phase 2]
This document describes a Phase 1/2 clinical trial evaluating the combination of gilteritinib and momelotinib in relapsed or refractory FLT3…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
A Phase 1 trial of regorafenib in combination with venetoclax and azacitidine for relapsed or refractory acute myeloid leukemia has been sus…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Clinical Study of Selinexor-Based Chemotherapy With Minimal or No Cytotoxic Agents in Treatment-Naïve AML Patients Unsuitable for Intensive Therapy: Focusing on Rapid Reduction of Blast Cells [NA]
A clinical study is planned to evaluate selinexor-based chemotherapy with minimal or no cytotoxic agents in treatment-naïve acute myeloid le…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: The Mutation Profile and Prognosis in AML With IDH1/2 Mutation
Clinical trial update on mutation profile and prognosis for acute myeloid leukemia patients with IDH1/2 mutations; the study status is termi…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Randomized Study of ABC-14 Regimen Compared With "3+7" Standard Induction Therapy or AB-14 for ND AML [Phase 2]
This clinical trial update describes a Phase 2 randomized study comparing the ABC-14 regimen with the 3+7 induction therapy or AB-14 for new…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Venetoclax + Azacitidine vs. Induction Chemotherapy in AML [Phase 2]
Phase 2 clinical trial comparing venetoclax plus azacitidine versus induction chemotherapy in acute myeloid leukemia, currently recruiting.
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant [Phase 1]
This clinical trial update describes a Phase 1 study evaluating HA-1 TCR T-cell immunotherapy for relapsed or refractory acute leukemia afte…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Phase I/II Clinical Trial of Universal Donor CD33 CAR Natural Killer Cells for AML [Phase 1, Phase 2]
A Phase I/II trial evaluating universal donor CD33 CAR natural killer cells for relapsed/refractory acute myeloid leukemia; the study status…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane [Phase 1]
Phase 1 clinical trial evaluating the highest dose of uproleselan in combination with fludarabine and cytarabine for relapsed or refractory …
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy [Phase 2]
Phase 2 trial evaluating hematopoietic stem cell transplantation using risk-adjusted chemotherapy for patients with Fanconi anemia and sever…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial update on Orca-T after chemotherapy and total marrow and lymphoid irradiation for acute myeloid leukemia, acute lymph…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML [Phase 1]
Phase 1 clinical trial evaluating danvatirsen as monotherapy followed by combination with venetoclax in relapsed/refractory myelodysplastic …
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Testing Oral Decitabine and Cedazuridine (ASTX727) in Combination With Venetoclax for Higher-Risk Acute Myeloid Leukemia Patients [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial is evaluating oral decitabine/cedazuridine (ASTX727) in combination with venetoclax for higher-risk acute m…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Novel Digital Application for Patients With Acute Leukemia [NA]
A clinical trial update describes a novel digital application for patients with relapsed, primary refractory, or high-risk acute myeloid leu…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia or Lymphoma With Cancer-Related Fatigue [Phase 2]
This Phase 2 trial evaluates cognitive behavioral therapy to reduce cancer-related fatigue in patients with acute myeloid leukemia and lymph…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia [Phase 2]
Phase 2 clinical trial evaluating a four-drug combination (cladribine, idarubicin, cytarabine, and venetoclax) for acute myeloid leukemia, h…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Personalized NK Cell Therapy in CBT [Phase 2]
A Phase 2 trial from MD Anderson is evaluating personalized NK cell therapy across several hematologic cancers. The study is currently recru…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse [Phase 1, Phase 2]
This clinical trial evaluates decitabine in combination with the FLAG-Ida chemotherapy regimen and total-body irradiation, followed by donor…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: UPDATE AML: UPdated Disease Monitoring And Treatment for Enhanced Outcomes for Pediatric AML [EARLY_Phase 1]
This clinical trial update describes an early-phase 1 study in pediatric acute myeloid leukemia, focusing on updated disease monitoring and …
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) [Phase 1]
This is a Phase 1 trial evaluating SL-401 (tagraxofusp) in combination with azacitidine or azacitidine plus venetoclax for acute myeloid leu…
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose) [Phase 2]
Phase 2 study update for participants who previously took ASTX727 (oral decitabine/cedazuridine) that is currently enrolling by invitation.
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome [Phase 2]
A Phase 2 trial evaluating ruxolitinib with tacrolimus and methotrexate to prevent graft-versus-host disease in pediatric and young adult pa…
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: Study of NMS-03597812 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial update for NMS-03597812 in adults with relapsed/refractory acute myeloid leukemia; currently recruiting.
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: Two Step Haplo With Radiation Conditioning [Phase 2]
Phase 2 clinical trial update describing two-step haploidentical transplantation with radiation conditioning for hematologic diseases, curre…
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CLINICAL_TRIALS research · 2025-10-27Clinical Trial Update: UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia [Phase 2]
Phase 2 clinical trial update for UM171 expanding cord blood in patients with high-risk acute leukemia or myelodysplastic syndromes. The stu…