Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Study Investigating the Safety of CD19 CAR-T Cells in Relapsed/Refractory AML Expressing CD19 [Phase 1]
A Phase 1 clinical trial is investigating the safety of CD19 CAR-T cells in patients with relapsed or refractory acute myeloid leukemia that…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors [Phase 2]
Phase 2 study evaluating exercise training with nicotinamide riboside (NR) supplementation to improve fitness in adolescent/young adult hema…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Sorafenib Combined With Venetoclax as Pre-emptive Therapy Strategy for MRD+ AML: a Prospective, Single-arm, Multicenter Clinical Study [Phase 2, Phase 3]
A prospective single-arm multicenter Phase 2/3 trial evaluating the combination of sorafenib and venetoclax as pre-emptive therapy for measu…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Expanded Natural Killer Cells Following Haploidentical HSCT for AML/MDS [Phase 1, Phase 2]
Clinical trial investigating expanded natural killer cells after haploidentical hematopoietic stem cell transplantation for acute myeloid le…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission [Phase 2]
A Phase 2 trial evaluating two dose levels of quizartinib as maintenance therapy in FLT3-ITD-positive acute myeloid leukemia patients in com…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Clinical Study of LILRA6 CAR-T for the Treatment of R/R Acute Myeloid Leukemia [Phase 1]
A Phase 1 study evaluating LILRA6 CAR-T therapy for relapsed or refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics [Phase 1]
Phase 1 study assessing how moderate renal impairment and race/ethnicity influence treosulfan pharmacokinetics in Acute Myeloid Leukemia and…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML [Phase 1]
A Phase I study of the selective nuclear export inhibitor KPT-330 (selinexor) in children with relapsed or refractory acute lymphoblastic le…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: A Study of (Interleukin-12) IL-12 in Patients With Acute Myelogenous Leukemia (AML) [Phase 1]
This clinical trial update describes a Phase 1 study of Interleukin-12 in patients with Acute Myeloid Leukemia, which is currently active bu…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell Transplantation [Phase 2]
A Phase 2 clinical trial is evaluating the feasibility and safety of donor-derived natural killer cell infusions to prevent leukemia relapse…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada
This clinical trial assesses change in disease state in adults with acute myeloid leukemia who are not eligible for intensive chemotherapy, …
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Correlation of Venetoclax Plasma Concentrations With Toxicity of Hypometilating Agents and Venetoclax Combination for Acute Myeloid Leukemia Patients in Remission.
Clinical trial update describing a study on how venetoclax plasma levels relate to toxicity when combined with hypomethylating agents in pat…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: OBServatory of Compassionate Use of IVOsidenib in France for Patients With Acute Myeloid Leukemia
This is a compassionate-use clinical trial in France enrolling adults with acute myeloid leukemia to receive ivosidenib (Tibsovo). The study…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: A Pivotal Study of APG-2575 (Lisaftoclax) Combined With Azacitidine in the Treatment of Acute Myeloid Leukemia [Phase 3]
Update on a Phase 3 pivotal trial evaluating APG-2575 (Lisaftoclax) in combination with Azacitidine for acute myeloid leukemia; the study is…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Study of the Medullary Microenvironment in Acute Childhood Leukemia [NA]
A pediatric clinical trial is investigating the medullary microenvironment in acute lymphoblastic leukemia and acute myeloid leukemia; the s…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Maintenance Venetoclax in AML Fit Patients [NA]
This clinical trial update notes that maintenance venetoclax is being studied in fit patients with acute myeloid leukemia and is currently r…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome [Phase 2]
This document provides a Phase 2 update on a recruiting trial evaluating CPX-351 plus Ivosidenib for IDH1-mutated acute myeloid leukemia and…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: PD-1 Inhibitor, Azacitidine and Low-dose DLI in AML Relapse After Allo-HSCT [NA]
Clinical trial evaluating the combination of a PD-1 inhibitor, azacitidine, and low-dose donor lymphocyte infusion for relapse of acute myel…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Venetoclax and Azacitidine Combined With Chidamide (VAC) for the Treatment of Newly Diagnosed Acute Monocytic Leukemia [Phase 2]
A Phase 2 clinical trial is evaluating the triple combination of venetoclax, azacitidine, and chidamide (VAC) for newly diagnosed acute mono…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Pilot Study of Reduced Venetoclax Exposure [Phase 2]
Phase 2 pilot study updating on reduced venetoclax exposure in patients with acute myeloid leukemia in remission; currently recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: The Efficacy of Therapy in Patients With Acute Myeloid Leukemia and Down Syndrome in Russia [Phase 3]
A Phase 3 clinical trial in Russia evaluating the efficacy of a therapy for patients with acute myeloid leukemia and Down syndrome is curren…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia [Phase 2]
Phase 2 clinical trial evaluating decitabine, venetoclax, and ponatinib for Philadelphia chromosome-positive acute myeloid leukemia and rela…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Optimization of Post-transplantation Benadamustine and Cyclophosphamide in Patients With High-risk Myeloid Malignancies and a Partially Mismatched Donor [Phase 2]
Phase 2 clinical trial update evaluating post-transplantation benadamustine and cyclophosphamide in high-risk myeloid malignancies with part…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Clinical Study to Evaluate the Safety and Efficacy of γδ T Cells for the Prevention of Relapse After Allogeneic Transplantation in Patients With High-risk Acute Myeloid Leukemia [NA]
This clinical trial is evaluating the safety and efficacy of gamma-delta T cell therapy to prevent relapse after allogeneic transplantation …
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Comparison of VA (Venetoclax, Azacitidine), VACl (VA, Cladribine), VACh (VA, Chidamide), and Alternating VACl/VACh in Newly Diagnosed Acute Myeloid Leukemia [Phase 2]
Phase 2 study evaluating venetoclax-based regimens with azacitidine, including combinations with cladribine or chidamide, or alternating VAC…