Acute Myeloid Leukemia with Npm1 Mutation
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, SNDX-5613, to the Standard Chemotherapy Treatment (Daunorubicin and Cytarabine) for Newly Diagnosed Patients With Acute Myeloid Leukemia That Has Changes in NPM1 or MLL/KMT2A Gene [Phase 1]
A Phase 1 clinical trial assessing adding SNDX-5613 to standard daunorubicin/cytarabine chemotherapy for newly diagnosed acute myeloid leuke…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1]
This Clinical Trial Update describes an ongoing Phase 1 study evaluating the safety and tolerability of ziftomenib in combination regimens f…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation [Phase 3]
This clinical trial update notes the ongoing Phase 3 study of Revumenib in combination with intensive chemotherapy for newly diagnosed acute…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML [Phase 1]
Phase 1 trial to assess the safety and tolerability of Ziftomenib in combination with Venetoclax/Azacitidine, Venetoclax alone, or 7+3 with …
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Study of BN104 in the Treatment of Acute Leukemia [Phase 1, Phase 2]
BN104 is being studied in Phase 1/2 trials for acute leukemia; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions
An observational clinical trial update on acute myeloid leukemia with an APL-like phenotype, focusing on distinct features and early vascula…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML [Phase 3]
Phase 3 trial evaluating Revumenib in combination with azacitidine and venetoclax for adults with NPM1-mutated or KMT2A-rearranged acute mye…
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CLINICAL_TRIALS research · 2024-12-02Clinical Trial Update: Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML [Phase 2]
This update describes a Phase 2 trial comparing venetoclax plus azacitidine against intensive chemotherapy in fit patients with newly diagno…