Decompensated Heart Failure
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2015-10-12Clinical Trial Update: Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment [NA]
Clinical trial update for aquapheresis versus IV diuretics in heart failure; study terminated with results posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-10-08Clinical Trial Update: A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF) [Phase 2]
A Phase IIb study evaluating intravenous Cinaciguat in patients with acute decompensated heart failure was terminated.
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CLINICAL_TRIALS trial_result · 2015-10-08Clinical Trial Update: A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF) [Phase 2]
This update reports the termination of a Phase IIb trial evaluating low-dose intravenous cinaciguat in patients with acute decompensated hea…
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CLINICAL_TRIALS trial_result · 2015-06-25Clinical Trial Update: Role of Natriuretic Peptides in the Treatment of Acutely Decompensated Heart Failure Patient With Obstructive Airways Disease [Phase 3]
A Phase 3 trial evaluating natriuretic peptides for acutely decompensated heart failure in patients with obstructive airway disease has been…
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CLINICAL_TRIALS trial_result · 2015-06-08Clinical Trial Update: Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics [NA]
The study compared ultrafiltration to diuretics in patients with acute decompensated heart failure to assess coronary flow reserve; the tria…
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CLINICAL_TRIALS trial_result · 2015-01-22Clinical Trial Update: Utility of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Predicting Renal Impairment, Further Decompensation and Rehospitalization in Acutely Decompensated and Chronic Heart Failure Patients
A completed clinical trial evaluating whether the biomarker NGAL can predict renal impairment, further decompensation, and rehospitalization…
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CLINICAL_TRIALS trial_result · 2014-12-03Clinical Trial Update: Serial Measurements of Biomarker in Patients With Acute Decompensated Heart Failure
The document reports on a completed clinical trial that involved serial biomarker measurements in patients with acute decompensated heart fa…
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CLINICAL_TRIALS trial_result · 2014-05-02Clinical Trial Update: Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure [Phase 2]
Phase 2 safety and efficacy study of Conivaptan (YM087) in patients with acute decompensated heart failure has completed. The trial status i…
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CLINICAL_TRIALS trial_result · 2014-03-24Clinical Trial Update: Biomonitoring and Cardiorenal Syndrome in Heart Failure(BIONICS-HF) Trial
Massachusetts General Hospital's BIONICS-HF trial, which investigates biomonitoring in cardiorenal syndrome within acute decompensated heart…
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CLINICAL_TRIALS trial_result · 2014-02-28Clinical Trial Update: An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure [Phase 3]
An open-label, single-arm Phase 3 trial evaluating the hemodynamic effects and safety of Nesiritide in acute decompensated heart failure has…
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CLINICAL_TRIALS trial_result · 2013-10-10Clinical Trial Update: Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure [Phase 3]
A Phase 3 trial tested six months of aliskiren added to standard therapy in patients with acute decompensated heart failure and reported on …
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CLINICAL_TRIALS trial_result · 2013-09-11Clinical Trial Update: Dopamine in Acute Decompensated Heart Failure II [Phase 4]
A Phase 4 trial evaluating dopamine for acute decompensated heart failure has been terminated.
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CLINICAL_TRIALS trial_result · 2013-08-30Clinical Trial Update: Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy [Phase 4]
Phase 4 clinical trial assessing biomarkers and cardiorenal syndrome in patients with Acute Decompensated Heart Failure receiving vasodilato…
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CLINICAL_TRIALS trial_result · 2013-06-24Clinical Trial Update: Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study) [Phase 3]
This Phase 3 trial update reports results from the CARRESS study comparing ultrafiltration to standard therapy in patients with acute decomp…
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CLINICAL_TRIALS trial_result · 2013-06-14Clinical Trial Update: Prognostic Relevance of High-sensitivity Troponin in Patients With Acute Decompensated Heart Failure
A completed clinical trial evaluating whether high-sensitivity troponin levels have prognostic value in patients with acute decompensated he…
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CLINICAL_TRIALS trial_result · 2013-04-23Clinical Trial Update: A Comparison of Recombinant Human Brain Natriuretic Peptide and Dobutamine
A completed clinical trial comparing recombinant human brain natriuretic peptide to dobutamine in patients with acute decompensated heart fa…
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CLINICAL_TRIALS trial_result · 2012-10-18Clinical Trial Update: PK/PD Study of Subcutaneous Cenderitide Infusion in CHF Patients [Phase 1]
Phase 1 PK/PD study evaluating subcutaneous infusion of Cenderitide (CD-NP) in heart failure patients has completed.
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CLINICAL_TRIALS trial_result · 2012-05-10Clinical Trial Update: A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure [Phase 3]
Phase 3 trial evaluating the effectiveness of nesiritide in patients with acute decompensated heart failure has completed and results were p…
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CLINICAL_TRIALS trial_result · 2012-02-22Clinical Trial Update: The Effects of Glucocorticoids on Mortality and Renal Function in Patients With Acute Decompensated Heart Failure [Phase 2, Phase 3]
A clinical trial update on Phase 2/3 study evaluating glucocorticoids for mortality and renal outcomes in patients with acute decompensated …
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CLINICAL_TRIALS trial_result · 2012-01-10Clinical Trial Update: Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration [Phase 3]
Phase 3 trial comparing diuretic therapy to ultrafiltration for cardiorenal interactions in acute decompensated heart failure has completed.…
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CLINICAL_TRIALS trial_result · 2011-11-01Clinical Trial Update: Troponin I Release After High Diuretic Doses [Phase 4]
A Phase 4 study in acute decompensated heart failure assessed troponin I release after high-dose diuretic therapy and has completed.
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CLINICAL_TRIALS trial_result · 2011-06-10Clinical Trial Update: A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. [Phase 3]
Phase 3 trial evaluating whether adding nesiritide to standard care improves blood flow, clinical outcomes, and safety in worsening congesti…
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CLINICAL_TRIALS trial_result · 2011-03-04Clinical Trial Update: A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels [Phase 3]
Phase 3 clinical trial update assessing safety and clinical experience with nesiritide (NATRECOR) in patients with worsening congestive hear…
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CLINICAL_TRIALS trial_result · 2010-10-22Clinical Trial Update: Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely Decompensated HF
This clinical trial update reports the completion of a study evaluating neutrophil gelatinase-associated lipocalin (NGAL) along with B-type …
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CLINICAL_TRIALS trial_result · 2010-10-01Clinical Trial Update: Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF) [Phase 3]
Phase 3 trial of conivaptan in hyponatremic patients with symptomatic acute decompensated heart failure was terminated; results were posted.