Catalyst Wire Dossier Catalyst Wire Dossier
CLINICAL_TRIALS trial_result · 2025-10-10

Clinical Trial Update: Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors [Phase 1]

View source ↗

Summary

A Phase 1 trial evaluating ribociclib in combination with topotecan and temozolomide (TOTEM) in pediatric patients with relapsed or refractory neuroblastoma and…

Upgrade for the full analysis, importance score, and drug timeline.

Diseases / indications

Drugs mentioned

  • Ribociclib (LEE011) (ribociclib)
  • Temozolomide (Temozolomide)
  • Topotecan (topotecan)

Snippet

Sponsor: Novartis Pharmaceuticals | Conditions: Neuroblastoma | Phase 1 | Status: TERMINATED