A Phase 1, Multicenter, Open-Label Study of REM-422, an MYB mRNA Degrader, in Patients With Relapsed/Refractory AML or Higher-Risk MDS

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT06297941

Title field or adapter rule

{'original_value': 'A Phase 1, Multicenter, Open-Label Study of REM-422, an MYB mRNA Degrader, in Patients With Relapsed/Refractory AML or Higher-Risk MDS', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-11-01T01:03:12.456435+00:00

Published At

2026-10-29T00:00:00+00:00

Record Updated At

2026-10-29

Source Retrieved At

2026-11-01T01:03:12.230707+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Myelodysplastic Syndromes", "Higher Risk Myelodysplastic Syndromes", "Acute Myeloid Leukemia", "Acute Myeloid Leukemia Refractory"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-29", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT06297941"

protocolSection.identificationModule.officialTitle

"A Phase 1, Multicenter, Open-Label Study of REM-422, an MYB mRNA Degrader, in Patients With Relapsed/Refractory AML or Higher-Risk MDS"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Myelodysplastic Syndromes (protocolSection.conditionsModule.conditions)
• Higher Risk Myelodysplastic Syndromes (protocolSection.conditionsModule.conditions)
• Acute Myeloid Leukemia (protocolSection.conditionsModule.conditions)
• Acute Myeloid Leukemia Refractory (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['REM-422'], 'description': 'REM-422 is a first in class, small molecule mRNA inhibitor that reduces expression of the MYB transcription factor\n\nREM-422 will be administered orally once daily', 'name': 'REM-422', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• REM-422 (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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