An Open-Label, Multicenter, Multi-arm Phase 1 Study Evaluating the Safety and Pharmacokinetics of ADU-1805 in Adults With Advanced Solid Tumors

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT05856981

Title field or adapter rule

{'original_value': 'An Open-Label, Multicenter, Multi-arm Phase 1 Study Evaluating the Safety and Pharmacokinetics of ADU-1805 in Adults With Advanced Solid Tumors', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-11-01T01:03:09.681028+00:00

Published At

2026-10-28T00:00:00+00:00

Record Updated At

2026-10-28

Source Retrieved At

2026-11-01T01:03:09.151179+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Solid Tumor, Adult", "Metastatic Solid Tumor", "Refractory Cancer", "CRC, Colorectal Cancer", "RCC, Clear Cell Adenocarcinoma", "NSCLC (Advanced Non-small Cell Lung Cancer)", "Endometrial Cancer"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-28", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT05856981"

protocolSection.identificationModule.officialTitle

"An Open-Label, Multicenter, Multi-arm Phase 1 Study Evaluating the Safety and Pharmacokinetics of ADU-1805 in Adults With Advanced Solid Tumors"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Solid Tumor, Adult (protocolSection.conditionsModule.conditions)
• Metastatic Solid Tumor (protocolSection.conditionsModule.conditions)
• Refractory Cancer (protocolSection.conditionsModule.conditions)
• CRC, Colorectal Cancer (protocolSection.conditionsModule.conditions)
• RCC, Clear Cell Adenocarcinoma (protocolSection.conditionsModule.conditions)
• NSCLC (Advanced Non-small Cell Lung Cancer) (protocolSection.conditionsModule.conditions)
• Endometrial Cancer (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Combination dose escalation, IV, Q3W, multiple dose levels, pembrolizumab at fixed dose', 'Combination dose expansion, IV, Q3W, multiple dose levels, pembrolizumab at fixed dose', 'Monotherapy dose escalation, IV, Q3W, multiple dose levels'], 'description': 'anti-SIRPα monoclonal antibody', 'name': 'ADU-1805', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Combination dose escalation, IV, Q3W, multiple dose levels, pembrolizumab at fixed dose', 'Combination dose expansion, IV, Q3W, multiple dose levels, pembrolizumab at fixed dose'], 'description': 'Keytruda', 'name': 'Pembrolizumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• ADU-1805 (protocolSection.armsInterventionsModule.interventions[].name)
• Pembrolizumab (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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