A Phase I Dose Finding and Phase II Randomized Trial of Iadademstat Combined With Immune Checkpoint Inhibition Maintenance After Initial Chemoimmunotherapy in Patients With Extensive-Stage Small Cell Lung Cancer

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT06287775

Title field or adapter rule

{'original_value': 'A Phase I Dose Finding and Phase II Randomized Trial of Iadademstat Combined With Immune Checkpoint Inhibition Maintenance After Initial Chemoimmunotherapy in Patients With Extensive-Stage Small Cell Lung Cancer', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-11-01T01:03:03.667850+00:00

Published At

2026-10-29T00:00:00+00:00

Record Updated At

2026-10-29

Source Retrieved At

2026-11-01T01:03:02.902675+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Extensive Stage Lung Small Cell Carcinoma", "Stage IV Lung Cancer AJCC v8"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-29", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT06287775"

protocolSection.identificationModule.officialTitle

"A Phase I Dose Finding and Phase II Randomized Trial of Iadademstat Combined With Immune Checkpoint Inhibition Maintenance After Initial Chemoimmunotherapy in Patients With Extensive-Stage Small Cell Lung Cancer"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Extensive Stage Lung Small Cell Carcinoma (protocolSection.conditionsModule.conditions)
• Stage IV Lung Cancer AJCC v8 (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Given IV', 'name': 'Atezolizumab', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Undergo optional tumor biopsy', 'name': 'Biopsy Procedure', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Undergo blood and urine sample collection', 'name': 'Biospecimen Collection', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Undergo CT scan', 'name': 'Computed Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Given IV', 'name': 'Durvalumab', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Undergo ECHO', 'name': 'Echocardiography Test', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Given PO', 'name': 'Iadademstat', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Undergo MRI', 'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (iadademstat, atezolizumab, durvalumab)', 'Phase II Arm II (atezolizumab, durvalumab)', 'Phase II, Arm I (iadademstat, atezolizumab, durvalumab)'], 'description': 'Undergo MUGA', 'name': 'Multigated Acquisition Scan', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• Iadademstat (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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