The Mechanism of Action Underlying Ketamine's Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT03973268

Title field or adapter rule

{'original_value': "The Mechanism of Action Underlying Ketamine's Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression", 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:37.146475+00:00

Published At

2026-10-30T00:00:00+00:00

Record Updated At

2026-10-30

Source Retrieved At

2026-10-31T22:19:07.580396+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Depression", "Major Depressive Disorder", "Major Depression"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-30", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT03973268"

protocolSection.identificationModule.officialTitle

"The Mechanism of Action Underlying Ketamine\u0027s Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Depression (protocolSection.conditionsModule.conditions)
• Major Depressive Disorder (protocolSection.conditionsModule.conditions)
• Major Depression (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['1', '2', '3'], 'description': 'MagPro 100 TMS Therapy System', 'name': 'Arm 1, 2, 3 device interventions', 'type': 'DEVICE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['2'], 'description': 'Placebo', 'name': 'Arm 2 Interventions', 'type': 'OTHER'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1', '2'], 'description': 'Ketamine', 'name': 'Arm 1, 2, 3 drug Interventions', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1', '2', '3'], 'description': 'Perampanel', 'name': 'Arm 1 and 2 Interventions', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• Arm 1, 2, 3 drug Interventions (protocolSection.armsInterventionsModule.interventions[].name)
• Arm 1 and 2 Interventions (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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