A Multicenter Phase I/Ib Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab in Patients With Selected Advanced or Metastatic Solid Tumors

This page presents selected fields from the linked source record. It does not add a medical interpretation.

Open original source record ↗

Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT05479812

Title field or adapter rule

{'original_value': 'A Multicenter Phase I/Ib Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab in Patients With Selected Advanced or Metastatic Solid Tumors', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:36.767771+00:00

Published At

2026-10-09T00:00:00+00:00

Record Updated At

2026-10-09

Source Retrieved At

2026-10-31T22:19:02.163121+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Metastatic Solid Tumor", "Advanced Solid Tumor"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-09", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT05479812"

protocolSection.identificationModule.officialTitle

"A Multicenter Phase I/Ib Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab in Patients With Selected Advanced or Metastatic Solid Tumors"

protocolSection.statusModule.overallStatus

"COMPLETED"

protocolSection.designModule.phases

["PHASE1"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Metastatic Solid Tumor (protocolSection.conditionsModule.conditions)
• Advanced Solid Tumor (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Arm A: WTX-124 monotherapy dose expansion. Patients with advanced or metastatic RCC.', 'Arm B: WTX-124 monotherapy dose expansion. Advanced or metastatic cutaneous malignant melanoma.', 'Arm C: WTX-124 monotherapy dose expansion. Patients with advanced or metastatic cSCC.', 'Arm D: WTX-124 in combination with pembro dose expansion. Advanced or metastatic RCC.', 'Arm E: WTX-124 with pembro dose expansion. Advanced or metastatic cutaneous melanoma.', 'Arm F: WTX-124 in combination with pembro dose expansion. Advanced/metastatic PD-L1-positive NSCL', 'WTX-124 in combination with pembro dose escalation', 'WTX-124 monotherapy dose escalation'], 'description': 'Investigation Product Monotherapy', 'name': 'WTX-124', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Arm D: WTX-124 in combination with pembro dose expansion. Advanced or metastatic RCC.', 'Arm E: WTX-124 with pembro dose expansion. Advanced or metastatic cutaneous melanoma.', 'Arm F: WTX-124 in combination with pembro dose expansion. Advanced/metastatic PD-L1-positive NSCL', 'WTX-124 in combination with pembro dose escalation'], 'description': 'Investigation Product in combination with approved therapy', 'name': 'pembrolizumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• WTX-124 (protocolSection.armsInterventionsModule.interventions[].name)
• pembrolizumab (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.