CLINICAL_TRIALS ClinicalTrials.gov record update

Phase 1 Study of Trastuzumab Deruxtecan (DS-8201a) in Combination With Azenosertib (ZN-c3) in HER2-Expressing/Amplified Gastric/Gastroesophageal Junction Cancer and Other Solid Tumors

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT06364410
Title field or adapter rule: {'original_value': 'Phase 1 Study of Trastuzumab Deruxtecan (DS-8201a) in Combination With Azenosertib (ZN-c3) in HER2-Expressing/Amplified Gastric/Gastroesophageal Junction Cancer and Other Solid Tumors', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:31.139676+00:00
Published At: 2026-10-27T00:00:00+00:00
Record Updated At: 2026-10-27
Source Retrieved At: 2026-10-31T22:18:28.651351+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Clinical Stage III Gastric Cancer AJCC v8", "Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8", "Clinical Stage IV Gastric Cancer AJCC v8", "Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8", "Locally Advanced Gastric Carcinoma", "Locally Advanced Gastroesophageal Junction Adenocarcinoma", "Locally Advanced Malignant Solid Neoplasm", "Metastatic Gastric Carcinoma", "Metastatic Gastroesophageal Junction Adenocarcinoma", "Metastatic Malignant Solid Neoplasm", "Unresectable Gastric Carcinoma", "Unresectable Gastroesophageal Junction Adenocarcinoma", "Unresectable Malignant Solid Neoplasm"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-27", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT06364410"
protocolSection.identificationModule.officialTitle: "Phase 1 Study of Trastuzumab Deruxtecan (DS-8201a) in Combination With Azenosertib (ZN-c3) in HER2-Expressing/Amplified Gastric/Gastroesophageal Junction Cancer and Other Solid Tumors"
protocolSection.statusModule.overallStatus: "RECRUITING"
protocolSection.designModule.phases: ["PHASE1"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Given PO', 'name': 'Azenosertib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Undergo biopsy', 'name': 'Biopsy Procedure', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Undergo collection of blood samples', 'name': 'Biospecimen Collection', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Undergo CT', 'name': 'Computed Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Undergo ECHO', 'name': 'Echocardiography Test', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Undergo MRI', 'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Undergo MUGA', 'name': 'Multigated Acquisition Scan', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose escalation (T-DXd, azenosertib)', 'Dose expansion, Cohort 1 (T-DXd, azenosertib)', 'Dose expansion, Cohort 2 (T-DXd, azenosertib)'], 'description': 'Given IV', 'name': 'Trastuzumab Deruxtecan', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

A recorded drug name is not by itself an indication or a condition-specific relationship.

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