CLINICAL_TRIALS ClinicalTrials.gov record update

Phase II Open-label, Multicentre, Randomized Trial of Neoadjuvant Palbociclib in Combination With Hormonal Therapy and HER2 Blockade Versus Paclitaxel in Combination With HER2 Blockade for Postmenopausal Patients With Hormone Receptor Positive/HER2 Positive Early Breast Cancer

This page presents selected fields from the linked source record. It does not add a medical interpretation.

Open original source record ↗

Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT03644186
Title field or adapter rule: {'original_value': 'Phase II Open-label, Multicentre, Randomized Trial of Neoadjuvant Palbociclib in Combination With Hormonal Therapy and HER2 Blockade Versus Paclitaxel in Combination With HER2 Blockade for Postmenopausal Patients With Hormone Receptor Positive/HER2 Positive Early Breast Cancer', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:30.843880+00:00
Published At: 2024-12-13T00:00:00+00:00
Record Updated At: 2026-10-21
Results Posted At: 2024-12-13
Source Retrieved At: 2026-10-31T22:18:24.976182+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Breast Cancer", "Estrogen Receptor Positive Tumor", "HER2-positive Breast Cancer"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-21", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT03644186"
protocolSection.identificationModule.officialTitle: "Phase II Open-label, Multicentre, Randomized Trial of Neoadjuvant Palbociclib in Combination With Hormonal Therapy and HER2 Blockade Versus Paclitaxel in Combination With HER2 Blockade for Postmenopausal Patients With Hormone Receptor Positive/HER2 Positive Early Breast Cancer"
protocolSection.statusModule.overallStatus: "COMPLETED"
protocolSection.designModule.phases: ["PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: {"date": "2024-12-13", "type": "ACTUAL"}

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['Paclitaxel plus trastuzumab and pertuzumab'], 'description': 'Chemotherapy plus HER2 Blockade', 'name': 'Paclitaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Paclitaxel plus trastuzumab and pertuzumab'], 'description': 'Chemotherapy plus HER2 Blockade', 'name': 'Trastuzumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Paclitaxel plus trastuzumab and pertuzumab'], 'description': 'Chemotherapy plus HER2 Blockade', 'name': 'Pertuzumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Palbociclib plus letrozole plus trastuzumab and pertuzumab'], 'description': 'CDK Inhibition plus Hormonal Therapy plus HER2 Blockade', 'name': 'Palbociclib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Palbociclib plus letrozole plus trastuzumab and pertuzumab'], 'description': 'CDK Inhibition plus Hormonal Therapy plus HER2 Blockade', 'name': 'Letrozole', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Palbociclib plus letrozole plus trastuzumab and pertuzumab'], 'description': 'CDK Inhibition plus Hormonal Therapy plus HER2 Blockade', 'name': 'Trastuzumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Palbociclib plus letrozole plus trastuzumab and pertuzumab'], 'description': 'CDK Inhibition plus Hormonal Therapy plus HER2 Blockade', 'name': 'Pertuzumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.