A Phase 2, Randomized, Multicenter, Open-label Neoadjuvant Study Evaluating Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT07102381

Title field or adapter rule

{'original_value': 'A Phase 2, Randomized, Multicenter, Open-label Neoadjuvant Study Evaluating Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:30.652016+00:00

Published At

2026-10-29T00:00:00+00:00

Record Updated At

2026-10-29

Source Retrieved At

2026-10-31T22:18:24.976182+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["HER2-positive Breast Cancer", "Breast Cancer"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-29", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT07102381"

protocolSection.identificationModule.officialTitle

"A Phase 2, Randomized, Multicenter, Open-label Neoadjuvant Study Evaluating Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• HER2-positive Breast Cancer (protocolSection.conditionsModule.conditions)
• Breast Cancer (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Zanidatamab with docetaxel and carboplatin', 'Zanidatamab with paclitaxel'], 'description': 'Administered intravenously (IV)', 'name': 'Zanidatamab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Zanidatamab with paclitaxel'], 'description': 'Administered intravenously (IV)', 'name': 'Paclitaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Trastuzumab and pertuzumab with docetaxel and carboplatin', 'Zanidatamab with docetaxel and carboplatin'], 'description': 'Administered intravenously (IV)', 'name': 'Docetaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Trastuzumab and pertuzumab with docetaxel and carboplatin', 'Zanidatamab with docetaxel and carboplatin'], 'description': 'Administered intravenously (IV)', 'name': 'Carboplatin', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Trastuzumab and pertuzumab with docetaxel and carboplatin'], 'description': 'Administered intravenously (IV)', 'name': 'Trastuzumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Trastuzumab and pertuzumab with docetaxel and carboplatin'], 'description': 'Administered intravenously (IV)', 'name': 'Pertuzumab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• Zanidatamab (protocolSection.armsInterventionsModule.interventions[].name)
• Paclitaxel (protocolSection.armsInterventionsModule.interventions[].name)
• Docetaxel (protocolSection.armsInterventionsModule.interventions[].name)
• Carboplatin (protocolSection.armsInterventionsModule.interventions[].name)
• Trastuzumab (protocolSection.armsInterventionsModule.interventions[].name)
• Pertuzumab (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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