A PHASE 1/2A STUDY EVALUATING THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-07220060 AS A SINGLE AGENT AND AS PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT04557449

Title field or adapter rule

{'original_value': 'A PHASE 1/2A STUDY EVALUATING THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-07220060 AS A SINGLE AGENT AND AS PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:30.256619+00:00

Published At

2026-10-28T00:00:00+00:00

Record Updated At

2026-10-28

Source Retrieved At

2026-10-31T22:18:19.086215+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Liposarcoma", "Prostate Cancer", "Advanced Breast Cancer", "NSCLC (Non-small Cell Lung Cancer)", "Colorectal Cancer"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-28", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT04557449"

protocolSection.identificationModule.officialTitle

"A PHASE 1/2A STUDY EVALUATING THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-07220060 AS A SINGLE AGENT AND AS PART OF COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Liposarcoma (protocolSection.conditionsModule.conditions)
• Prostate Cancer (protocolSection.conditionsModule.conditions)
• Advanced Breast Cancer (protocolSection.conditionsModule.conditions)
• NSCLC (Non-small Cell Lung Cancer) (protocolSection.conditionsModule.conditions)
• Colorectal Cancer (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['1A Monotherapy Escalation Arm 1', '1A Monotherapy Escalation Arm 2', '1A Monotherapy Escalation Arm 3', '1A Monotherapy Escalation Arm 4', '1A Monotherapy Escalation Arm 5', '1B Combination Dose Finding Arm 1', '1B Combination Dose Finding Arm 2', '1C Combination Dose Finding Arm 1', '1C Combination Dose Finding Arm 2', '1D Monotherapy Food Effect', '1E DDI Cohort', '1F Combination Dose Finding', '1G Combination Dose Finding Arm 1', '2A Combination Dose Expansion', '2B Combination Dose Expansion', '2C Combination Dose Expansion', '2E Combination Dose Expansion', '2F Combination Dose Expansion', 'Giredestrant Combination Cohort (Group A)', 'Giredestrant Combination Cohort (Group B)'], 'description': 'CDK4 inhibitor', 'name': 'PF-07220060', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1B Combination Dose Finding Arm 1', '1B Combination Dose Finding Arm 2', '2B Combination Dose Expansion'], 'description': 'Endocrine Therapy', 'name': 'Letrozole', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1C Combination Dose Finding Arm 1', '1C Combination Dose Finding Arm 2', '2A Combination Dose Expansion', '2C Combination Dose Expansion', '2E Combination Dose Expansion'], 'description': 'Endocrine Therapy', 'name': 'Fulvestrant', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1E DDI Cohort'], 'description': 'Benzodiazepine', 'name': 'Midazolam', 'type': 'OTHER'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1F Combination Dose Finding'], 'description': 'Androgen Receptor inhibitor', 'name': 'Enzalutamide', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Giredestrant Combination Cohort (Group A)', 'Giredestrant Combination Cohort (Group B)'], 'description': 'Endocrine Therapy', 'name': 'Giredestrant', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['1G Combination Dose Finding Arm 1', '2F Combination Dose Expansion'], 'description': 'Endocrine Therapy', 'name': 'Tamoxifen', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• PF-07220060 (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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