CLINICAL_TRIALS ClinicalTrials.gov record update

A Phase II Randomized Study Comparing BTK Inhibitors (Ibrutinib Plus Rituximab or Zanubrutinib Alone) vs. BCL-2 Inhibitor (Venetoclax) and Rituximab in Previously Untreated Waldenström's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT04840602
Title field or adapter rule: {'original_value': "A Phase II Randomized Study Comparing BTK Inhibitors (Ibrutinib Plus Rituximab or Zanubrutinib Alone) vs. BCL-2 Inhibitor (Venetoclax) and Rituximab in Previously Untreated Waldenström's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)", 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:29.385249+00:00
Published At: 2026-10-30T00:00:00+00:00
Record Updated At: 2026-10-30
Source Retrieved At: 2026-10-31T22:18:11.341859+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Lymphoplasmacytic Lymphoma", "Waldenstrom Macroglobulinemia"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-30", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT04840602"
protocolSection.identificationModule.officialTitle: "A Phase II Randomized Study Comparing BTK Inhibitors (Ibrutinib Plus Rituximab or Zanubrutinib Alone) vs. BCL-2 Inhibitor (Venetoclax) and Rituximab in Previously Untreated Waldenstr\u00f6m\u0027s Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)"
protocolSection.statusModule.overallStatus: "RECRUITING"
protocolSection.designModule.phases: ["PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)', 'Arm II (venetoclax, rituximab)'], 'description': 'Undergo blood sample collection', 'name': 'Biospecimen Collection', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)', 'Arm II (venetoclax, rituximab)'], 'description': 'Undergo bone marrow biopsy and aspiration', 'name': 'Bone Marrow Aspiration', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)', 'Arm II (venetoclax, rituximab)'], 'description': 'Undergo bone marrow biopsy and aspiration', 'name': 'Bone Marrow Biopsy', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)', 'Arm II (venetoclax, rituximab)'], 'description': 'Undergo CT or PET/CT', 'name': 'Computed Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)'], 'description': 'Given PO', 'name': 'Ibrutinib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)', 'Arm II (venetoclax, rituximab)'], 'description': 'Undergo PET/CT', 'name': 'Positron Emission Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)', 'Arm II (venetoclax, rituximab)'], 'description': 'Given IV', 'name': 'Rituximab', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm II (venetoclax, rituximab)'], 'description': 'Given PO', 'name': 'Venetoclax', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm I (ibrutinib + rituximab or zanubrutinib)'], 'description': 'Given PO', 'name': 'Zanubrutinib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

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