CLINICAL_TRIALS ClinicalTrials.gov record update

Phase II Haploidentical Hematopoietic Stem Cell Transplantation for Participants With Germline RUNX1 Associated Hematologic Malignancies

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT07524530
Title field or adapter rule: {'original_value': 'Phase II Haploidentical Hematopoietic Stem Cell Transplantation for Participants With Germline RUNX1 Associated Hematologic Malignancies', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:29.073987+00:00
Published At: 2026-10-30T00:00:00+00:00
Record Updated At: 2026-10-30
Source Retrieved At: 2026-10-31T22:18:11.341859+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Core Binding Factor Alpha Subunits", "Hematologic Neoplasms", "Leukemia", "Lymphoma"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-30", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT07524530"
protocolSection.identificationModule.officialTitle: "Phase II Haploidentical Hematopoietic Stem Cell Transplantation for Participants With Germline RUNX1 Associated Hematologic Malignancies"
protocolSection.statusModule.overallStatus: "NOT_YET_RECRUITING"
protocolSection.designModule.phases: ["PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['Arm 1', 'Arm 2'], 'description': 'For Arm 1 myeloablative conditioning, given on days -6 and -5 at 50 mg/kg/day IV.\n\nFor Arm 2 reduced intensity conditioning, give on day -5 and day -4 at 14.5 mg/kg IV once daily.\n\nGVHD prophylaxis for all recipients, 50mg/kg IV on Day 3 and Day 4 post HSCT.', 'name': 'Cyclophosphamide', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm 1'], 'description': 'For Arm 1 myeloablative conditioning, given on day -4 to day -1. The daily busulfan area under the curve goal is 4263-4872 mcMolar x min daily or 17.5-20 mg/hr/L per day (70-80 mg\\*hr/L over 4 days).', 'name': 'Busulfan', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm 2'], 'description': 'For Arm 2 reduced intensity conditioning, given once daily on days -5 through day -2. The cumulative fludarabine area under the curve is 20 mg\\*hr/mL', 'name': 'Fludarabine', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm 2'], 'description': 'Form Arm 2 reduced intensity conditioning, total 4 Gy, fractionated 2 Gy twice per day, given on day -1.', 'name': 'Total Body Irradiation', 'type': 'RADIATION'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm 1', 'Arm 2'], 'description': 'Given on Day 0. The target dose is any dose \\> or equal to 7 x 10\\^6 and \\<= 10 x 10\\^6 CD34+ cells/kg recipient body weight.', 'name': 'Hematopoietic stem cells', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm 1', 'Arm 2'], 'description': 'GVHD prophylaxis for all recipients. Given intravenously at a dose of .02 mg/kg from Day 5 until Day 100.', 'name': 'Tacrolimus', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm 1', 'Arm 2'], 'description': 'GVHD prophylaxis for all recipients. Given at a dose of 15 mg/kg three times a day from Day 5 through Day 35.', 'name': 'Mycophenolate Mofetil', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.