CLINICAL_TRIALS ClinicalTrials.gov record update

A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-08165784 MONOTHERAPY AND COMBINATIONS IN PARTICIPANTS WITH PIK3CA-MUTATED ADVANCED OR METASTATIC SOLID TUMORS

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT07897721
Title field or adapter rule: {'original_value': 'A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-08165784 MONOTHERAPY AND COMBINATIONS IN PARTICIPANTS WITH PIK3CA-MUTATED ADVANCED OR METASTATIC SOLID TUMORS', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:28.897784+00:00
Published At: 2026-10-28T00:00:00+00:00
Record Updated At: 2026-10-28
Source Retrieved At: 2026-10-31T22:18:26.854673+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["Advanced Breast Cancer", "Advanced or Metastatic Breast Cancer", "Metastatic Breast Cancer (HR+/ HER2-)", "Metastatic Colorectal Adenocarcinoma"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-28", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT07897721"
protocolSection.identificationModule.officialTitle: "A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTI-TUMOR ACTIVITY OF PF-08165784 MONOTHERAPY AND COMBINATIONS IN PARTICIPANTS WITH PIK3CA-MUTATED ADVANCED OR METASTATIC SOLID TUMORS"
protocolSection.statusModule.overallStatus: "NOT_YET_RECRUITING"
protocolSection.designModule.phases: ["PHASE1"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Part 1 Dose Escalation Cohort 1A', 'Part 1 Dose Escalation Cohort 1B', 'Part 1 Dose Escalation Cohort 1C', 'Part 1 Dose Escalation Cohort 1D', 'Part 2 Dose Optimization/Expansion Cohort 2A'], 'description': 'Taken by mouth (PO)', 'name': 'PF-08165784', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 1 Dose Escalation Cohort 1B', 'Part 1 Dose Escalation Cohort 1C'], 'description': 'Selective Estrogen Receptor Degrader (SERD)', 'name': 'Fulvestrant', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 1 Dose Escalation Cohort 1C', 'Part 2 Dose Optimization/Expansion Cohort 2A'], 'description': 'Selective cyclin-dependent kinase 4 (CDK4) inhibitor', 'name': 'Atirmociclib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 1 Dose Escalation Cohort 1D'], 'description': 'Monoclonal antibody (EGFR inhibitor)', 'name': 'Cetuximab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 2 Dose Optimization/Expansion Cohort 2A'], 'description': 'Nonsteroidal aromatase inhibitor', 'name': 'Letrozole', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.