CLINICAL_TRIALS ClinicalTrials.gov record update

MK-5684-01A Substudy: A Phase 1/2 Umbrella Substudy of MK-5684-U01 Master Protocol to Evaluate the Safety and Efficacy of MK-5684-based Treatment Combinations or MK-5684 Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)

This page presents selected fields from the linked source record. It does not add a medical interpretation.

Open original source record ↗

Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT06353386
Title field or adapter rule: {'original_value': 'MK-5684-01A Substudy: A Phase 1/2 Umbrella Substudy of MK-5684-U01 Master Protocol to Evaluate the Safety and Efficacy of MK-5684-based Treatment Combinations or MK-5684 Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:28.676952+00:00
Published At: 2026-10-29T00:00:00+00:00
Record Updated At: 2026-10-29
Source Retrieved At: 2026-10-31T22:18:05.512861+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Prostatic Neoplasms, Castration-Resistant"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-29", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT06353386"
protocolSection.identificationModule.officialTitle: "MK-5684-01A Substudy: A Phase 1/2 Umbrella Substudy of MK-5684-U01 Master Protocol to Evaluate the Safety and Efficacy of MK-5684-based Treatment Combinations or MK-5684 Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC)"
protocolSection.statusModule.overallStatus: "ACTIVE_NOT_RECRUITING"
protocolSection.designModule.phases: ["PHASE1", "PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['Arm A1: Opevesostat', 'Arm A2: Olaparib + Opevesostat', 'Arm A3: Docetaxel + Opevesostat', 'Arm A4: Cabazitaxel + Opevesostat'], 'description': 'Oral Tablet', 'name': 'Opevesostat', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm A2: Olaparib + Opevesostat'], 'description': 'Oral Tablet', 'name': 'Olaparib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm A3: Docetaxel + Opevesostat'], 'description': 'IV Infusion', 'name': 'Docetaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm A4: Cabazitaxel + Opevesostat'], 'description': 'IV Infusion', 'name': 'Cabazitaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm A1: Opevesostat', 'Arm A2: Olaparib + Opevesostat', 'Arm A3: Docetaxel + Opevesostat', 'Arm A4: Cabazitaxel + Opevesostat'], 'description': 'Oral Tablet', 'name': 'Fludrocortisone acetate', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm A1: Opevesostat', 'Arm A2: Olaparib + Opevesostat', 'Arm A3: Docetaxel + Opevesostat', 'Arm A4: Cabazitaxel + Opevesostat'], 'description': 'Oral Tablet', 'name': 'Dexamethasone', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Arm A3: Docetaxel + Opevesostat', 'Arm A4: Cabazitaxel + Opevesostat'], 'description': 'Oral Tablet', 'name': 'Prednisone', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.