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CLINICAL_TRIALS ClinicalTrials.gov record update

A Randomized, Open-label, Phase 3 Study of MK-2870 vs. Platinum Doublets in Participants With EGFR-mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors

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Record identity and dates

Source
ClinicalTrials.gov
Source record ID
NCT06305754
Title field or adapter rule
{'original_value': 'A Randomized, Open-label, Phase 3 Study of MK-2870 vs. Platinum Doublets in Participants With EGFR-mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At
2026-10-31T23:27:28.149989+00:00
Published At
2026-10-30T00:00:00+00:00
Record Updated At
2026-10-30
Source Retrieved At
2026-10-31T22:18:03.495925+00:00
Timestamp Basis
ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation
ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions
["Non-small Cell Lung Cancer (NSCLC)"]
protocolSection.statusModule.lastUpdatePostDateStruct
{"date": "2026-10-30", "type": "ACTUAL"}
protocolSection.identificationModule.nctId
"NCT06305754"
protocolSection.identificationModule.officialTitle
"A Randomized, Open-label, Phase 3 Study of MK-2870 vs. Platinum Doublets in Participants With EGFR-mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors"
protocolSection.statusModule.overallStatus
"ACTIVE_NOT_RECRUITING"
protocolSection.designModule.phases
["PHASE3"]
protocolSection.statusModule.resultsFirstPostDateStruct
null

Study condition terms

  • Non-small Cell Lung Cancer (NSCLC) (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

  • {'armGroupLabels': ['Sacituzumab tirumotecan'], 'description': '4 mg/kg via IV infusion', 'name': 'Sacituzumab tirumotecan', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Pemetrexed Plus Carboplatin'], 'description': '500 mg/m\\^2 via IV infusion', 'name': 'Pemetrexed', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Pemetrexed Plus Carboplatin'], 'description': 'AUC 5 mg/mL\\*min via IV infusion', 'name': 'Carboplatin', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Sacituzumab tirumotecan'], 'description': 'Administered as rescue medication per approved product label', 'name': 'H1 Receptor Antagonist', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Sacituzumab tirumotecan'], 'description': 'Administered as rescue medication per approved product label', 'name': 'H2 Receptor Antagonist', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Sacituzumab tirumotecan'], 'description': 'Administered as rescue medication per approved product label', 'name': 'Acetaminophen (or equivalent)', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Sacituzumab tirumotecan'], 'description': 'Administered as rescue medication per approved product label', 'name': 'Dexamethasone (or equivalent)', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
  • {'armGroupLabels': ['Sacituzumab tirumotecan'], 'description': 'Administered as rescue medication per approved product label', 'name': 'Steroid Mouthwash (dexamethasone or equivalent)', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

  • Pemetrexed (protocolSection.armsInterventionsModule.interventions[].name)
  • Carboplatin (protocolSection.armsInterventionsModule.interventions[].name)
  • H1 Receptor Antagonist (protocolSection.armsInterventionsModule.interventions[].name)
  • H2 Receptor Antagonist (protocolSection.armsInterventionsModule.interventions[].name)
  • Acetaminophen (or equivalent) (protocolSection.armsInterventionsModule.interventions[].name)
  • Dexamethasone (or equivalent) (protocolSection.armsInterventionsModule.interventions[].name)
  • Steroid Mouthwash (dexamethasone or equivalent) (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.