CLINICAL_TRIALS ClinicalTrials.gov record update

Molecular Analysis for Combination Therapy Choice (ComboMATCH)

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT05564377
Title field or adapter rule: {'original_value': 'Molecular Analysis for Combination Therapy Choice (ComboMATCH)', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:27.372270+00:00
Published At: 2026-10-30T00:00:00+00:00
Record Updated At: 2026-10-30
Source Retrieved At: 2026-10-31T22:18:19.086215+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Advanced Malignant Solid Neoplasm", "Anatomic Stage III Breast Cancer AJCC v8", "Anatomic Stage IV Breast Cancer AJCC v8", "Locally Advanced Malignant Solid Neoplasm", "Malignant Female Reproductive System Neoplasm", "Metastatic HER2-Negative Breast Carcinoma", "Metastatic Malignant Solid Neoplasm", "Recurrent Endometrial Carcinoma", "Recurrent Fallopian Tube Carcinoma", "Recurrent Malignant Female Reproductive System Neoplasm", "Recurrent Malignant Solid Neoplasm", "Recurrent Ovarian Carcinoma", "Recurrent Primary Peritoneal Carcinoma", "Unresectable HER2-Negative Breast Carcinoma", "Unresectable Malignant Solid Neoplasm"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-30", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT05564377"
protocolSection.identificationModule.officialTitle: "Molecular Analysis for Combination Therapy Choice (ComboMATCH)"
protocolSection.statusModule.overallStatus: "RECRUITING"
protocolSection.designModule.phases: ["PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 3, Arm D)'], 'description': 'Given PO', 'name': 'Alpelisib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A3 Monotherapy Cohort 1 (binimetinib)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)'], 'description': 'Given PO', 'name': 'Binimetinib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A2 (Cohort 3, Arm D)', 'EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'EAY191-A3 Monotherapy Cohort 1 (binimetinib)', 'EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-E4 (taxane therapy)', 'EAY191-E5 Cohort I Arm A (sotorasib, panitumumab)', 'EAY191-E5 Cohort I Arm B (sotorasib)', 'EAY191-E5 Cohort II (sotorasib)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)', 'EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)', 'EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)', 'EAY191-S3 (activating AKT mutation)'], 'description': 'Undergo biopsy', 'name': 'Biopsy Procedure', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A2 (Cohort 3, Arm D)', 'EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'EAY191-A3 Monotherapy Cohort 1 (binimetinib)', 'EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-E4 (taxane therapy)', 'EAY191-E5 Cohort I Arm A (sotorasib, panitumumab)', 'EAY191-E5 Cohort I Arm B (sotorasib)', 'EAY191-E5 Cohort II (sotorasib)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)', 'EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)', 'EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)', 'EAY191-S3 (activating AKT mutation)'], 'description': 'Undergo blood collection', 'name': 'Biospecimen Collection', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)'], 'description': 'Undergo bone marrow aspiration', 'name': 'Bone Marrow Aspiration', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)'], 'description': 'Undergo bone marrow biopsy', 'name': 'Bone Marrow Biopsy', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A2 (Cohort 3, Arm D)', 'EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'EAY191-A3 Monotherapy Cohort 1 (binimetinib)', 'EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)'], 'description': 'Undergo bone scan', 'name': 'Bone Scan', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A2 (Cohort 3, Arm D)', 'EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'EAY191-A3 Monotherapy Cohort 1 (binimetinib)', 'EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-E4 (taxane therapy)', 'EAY191-E5 Cohort I Arm A (sotorasib, panitumumab)', 'EAY191-E5 Cohort I Arm B (sotorasib)', 'EAY191-E5 Cohort II (sotorasib)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)', 'EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)', 'EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)', 'EAY191-S3 (activating AKT mutation)'], 'description': 'Undergo CT', 'name': 'Computed Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)', 'EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)', 'EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)'], 'description': 'Undergo ECHO', 'name': 'Echocardiography Test', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)'], 'description': 'Given IV', 'name': 'Fluorouracil', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)'], 'description': 'Given IM', 'name': 'Fulvestrant', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-S3 (activating AKT mutation)'], 'description': 'Given PO', 'name': 'Ipatasertib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)'], 'description': 'Given IV', 'name': 'Leucovorin', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'EAY191-A3 Monotherapy Cohort 1 (binimetinib)', 'EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-E4 (taxane therapy)', 'EAY191-E5 Cohort I Arm A (sotorasib, panitumumab)', 'EAY191-E5 Cohort I Arm B (sotorasib)', 'EAY191-E5 Cohort II (sotorasib)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)', 'EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)', 'EAY191-S3 (activating AKT mutation)'], 'description': 'Undergo MRI', 'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)', 'EAY191-N2 Cohort I (Arm I) (NF1 mutations)', 'EAY191-N2 Cohort I (Arm II) (NF1 mutations)', 'EAY191-N2 Cohort II (NF1 mutations)', 'EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)', 'EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)'], 'description': 'Undergo MUGA', 'name': 'Multigated Acquisition Scan', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)'], 'description': 'Undergo tumor mutational screening', 'name': 'Mutation Carrier Screening', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-N5 Arm I (neratinib maleate)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)'], 'description': 'Given PO', 'name': 'Neratinib Maleate', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-E4 (taxane therapy)'], 'description': 'Given PO', 'name': 'Nilotinib Hydrochloride Monohydrate', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A2 (Cohort 3, Arm D)', 'EAY191-N4 Arm I (RAS pathway mutations)'], 'description': 'Given PO', 'name': 'Olaparib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)'], 'description': 'Given IV', 'name': 'Oxaliplatin', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-E4 (taxane therapy)', 'EAY191-S3 (activating AKT mutation)'], 'description': 'Given PO or IV', 'name': 'Paclitaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A3 Combo Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'EAY191-N5 Arm II (neratinib maleate,palbociclib)'], 'description': 'Given PO', 'name': 'Palbociclib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-E5 Cohort I Arm A (sotorasib, panitumumab)', 'EAY191-E5 Cohort II (sotorasib)'], 'description': 'Given IV', 'name': 'Panitumumab', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-A2 (Cohort 1, Arm A)', 'EAY191-A2 (Cohort 2, Arm B)', 'EAY191-A2 (Cohort 2, Arm C)', 'EAY191-A2 (Cohort 3, Arm D)', 'EAY191-A6 Arm I (RAS/RAF/MEK/ERK mutations)', 'EAY191-A6 Arm II (RAS/RAF/MEK/ERK mutations)'], 'description': 'Undergo PET', 'name': 'Positron Emission Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-N4 Arm I (RAS pathway mutations)', 'EAY191-N4 Arm II (RAS pathway mutations)'], 'description': 'Given PO', 'name': 'Selumetinib Sulfate', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['EAY191-E5 Cohort I Arm A (sotorasib, panitumumab)', 'EAY191-E5 Cohort I Arm B (sotorasib)', 'EAY191-E5 Cohort II (sotorasib)'], 'description': 'Given PO', 'name': 'Sotorasib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.