CLINICAL_TRIALS ClinicalTrials.gov record update

A Phase 1/2 Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT04902872
Title field or adapter rule: {'original_value': 'A Phase 1/2 Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:27.133984+00:00
Published At: 2026-08-20T00:00:00+00:00
Record Updated At: 2026-08-20
Source Retrieved At: 2026-10-31T22:17:58.991924+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["Solid Tumor, Adult", "Epithelial Ovarian Cancer", "Small Cell Lung Carcinoma", "Breast Cancer", "Colorectal Cancer", "Pancreas Cancer", "Appendix Cancer", "Non-small Cell Lung Cancer", "Gastric Cancer", "Esophagus Cancer", "Urothelial Carcinoma", "Sarcoma"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-08-20", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT04902872"
protocolSection.identificationModule.officialTitle: "A Phase 1/2 Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors"
protocolSection.statusModule.overallStatus: "COMPLETED"
protocolSection.designModule.phases: ["PHASE1", "PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Phase 1 Modified Schedule B Dose Escalation (Once Every 3 weeks)', 'Phase 1 Schedule A Dose Escalation (Daily Dosing x 5)', 'Phase 1 Schedule B Dose Escalation (Daily Dosing x 3)', 'Phase 1 Schedule C Dose Escalation (Once Weekly Dosing )', 'Phase 2 Metastatic Breast Expansion Cohort', 'Phase 2 Ovarian Cancer Expansion Cohort'], 'description': 'CBX-12 is an alphalex construct which consists of a low-pH insertion peptide, a self-immolating linker, and exatecan as the pharmacologically active moiety', 'name': 'CBX-12', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

A recorded drug name is not by itself an indication or a condition-specific relationship.

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