CLINICAL_TRIALS ClinicalTrials.gov record update

Palbociclib and Binimetinib in RAS-Mutant Cancers: A ComboMATCH Treatment Trial

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT05554367
Title field or adapter rule: {'original_value': 'Palbociclib and Binimetinib in RAS-Mutant Cancers: A ComboMATCH Treatment Trial', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:27.122953+00:00
Published At: 2026-08-21T00:00:00+00:00
Record Updated At: 2026-08-21
Source Retrieved At: 2026-10-31T22:17:58.991924+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions: ["Exocrine Pancreas Carcinoma", "Malignant Solid Neoplasm", "Ovarian Low Grade Serous Adenocarcinoma", "Stage IV Ovarian Cancer AJCC v8", "Stage IV Pancreatic Cancer AJCC v8"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-08-21", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT05554367"
protocolSection.identificationModule.officialTitle: "Palbociclib and Binimetinib in RAS-Mutant Cancers: A ComboMATCH Treatment Trial"
protocolSection.statusModule.overallStatus: "ACTIVE_NOT_RECRUITING"
protocolSection.designModule.phases: ["PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

Study condition terms

Interventions recorded in this study

{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'Monotherapy Cohort 1 (binimetinib)'], 'description': 'Given PO', 'name': 'Binimetinib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'Monotherapy Cohort 1 (binimetinib)'], 'description': 'Undergo biopsy', 'name': 'Biopsy Procedure', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'Monotherapy Cohort 1 (binimetinib)'], 'description': 'Undergo collection of blood samples', 'name': 'Biospecimen Collection', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'Monotherapy Cohort 1 (binimetinib)'], 'description': 'Undergo bone scan', 'name': 'Bone Scan', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'Monotherapy Cohort 1 (binimetinib)'], 'description': 'Undergo CT', 'name': 'Computed Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)', 'Monotherapy Cohort 1 (binimetinib)'], 'description': 'Undergo MRI', 'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Combination Cohorts 1, 2, 3, 4 (palbociclib, binimetinib)'], 'description': 'Given PO', 'name': 'Palbociclib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

A recorded drug name is not by itself an indication or a condition-specific relationship.

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