Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma: A Phase IB/II Safety and Efficacy Study

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT07824960

Title field or adapter rule

{'original_value': 'Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma: A Phase IB/II Safety and Efficacy Study', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:25.570030+00:00

Published At

2026-09-17T00:00:00+00:00

Record Updated At

2026-09-17

Source Retrieved At

2026-10-31T22:17:56.788771+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Pancreatic Cancer", "PDAC - Pancreatic Ductal Adenocarcinoma", "Metastatic Pancreatic Carcinoma", "Locally Advanced Pancreatic Cancer"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-09-17", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT07824960"

protocolSection.identificationModule.officialTitle

"Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma: A Phase IB/II Safety and Efficacy Study"

protocolSection.statusModule.overallStatus

"NOT_YET_RECRUITING"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Pancreatic Cancer (protocolSection.conditionsModule.conditions)
• PDAC - Pancreatic Ductal Adenocarcinoma (protocolSection.conditionsModule.conditions)
• Metastatic Pancreatic Carcinoma (protocolSection.conditionsModule.conditions)
• Locally Advanced Pancreatic Cancer (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Neoadjuvant avutometinib + defactinib with standard of care chemotherapy'], 'description': 'Participants will receive avutometinib and defactinib in combination with mFOLFIRINOX (standard of care chemotherapy) in 28-day cycles for up to 6 cycles.', 'name': 'Avutometinib (VS-6766) + Defactinib (VS-6063)', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• Avutometinib (VS-6766) + Defactinib (VS-6063) (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.