Phase 1/1b, Multicenter, Open-Label, Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

This page presents selected fields from the linked source record. It does not add a medical interpretation.

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT07349537

Title field or adapter rule

{'original_value': 'Phase 1/1b, Multicenter, Open-Label, Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:25.485824+00:00

Published At

2026-09-17T00:00:00+00:00

Record Updated At

2026-09-17

Source Retrieved At

2026-10-31T22:17:56.788771+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Non-small Cell Lung Cancer (NSCLC)", "Colorectal Cancer (CRC)", "Pancreatic Adenocarcinoma", "Pancreatic Ductal Adenocarcinoma (PDAC)", "PDAC", "CRC", "NSCLC", "Pancreatic Cancer", "Lung Cancer (NSCLC)", "Advanced Solid Tumors"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-09-17", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT07349537"

protocolSection.identificationModule.officialTitle

"Phase 1/1b, Multicenter, Open-Label, Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Non-small Cell Lung Cancer (NSCLC) (protocolSection.conditionsModule.conditions)
• Colorectal Cancer (CRC) (protocolSection.conditionsModule.conditions)
• Pancreatic Adenocarcinoma (protocolSection.conditionsModule.conditions)
• Pancreatic Ductal Adenocarcinoma (PDAC) (protocolSection.conditionsModule.conditions)
• PDAC (protocolSection.conditionsModule.conditions)
• CRC (protocolSection.conditionsModule.conditions)
• NSCLC (protocolSection.conditionsModule.conditions)
• Pancreatic Cancer (protocolSection.conditionsModule.conditions)
• Lung Cancer (NSCLC) (protocolSection.conditionsModule.conditions)
• Advanced Solid Tumors (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Arm A: RMC-5127 Monotherapy', 'Arm B: RMC-5127 + Daraxonrasib Combination', 'Arm C: RMC-5127 + Cetuximab Combination'], 'description': 'oral tablets', 'name': 'RMC-5127', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Arm B: RMC-5127 + Daraxonrasib Combination'], 'description': 'oral tablets', 'name': 'daraxonrasib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Arm C: RMC-5127 + Cetuximab Combination'], 'description': 'IV infusion', 'name': 'cetuximab', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• RMC-5127 (protocolSection.armsInterventionsModule.interventions[].name)
• daraxonrasib (protocolSection.armsInterventionsModule.interventions[].name)
• cetuximab (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.