CLINICAL_TRIALS ClinicalTrials.gov record update

A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT04644068
Title field or adapter rule: {'original_value': 'A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:25.285865+00:00
Published At: 2026-09-21T00:00:00+00:00
Record Updated At: 2026-09-21
Source Retrieved At: 2026-10-31T22:17:56.788771+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["Ovarian Cancer", "Breast Cancer", "Pancreatic Cancer", "Prostate Cancer", "Additional Indications Below for Module 4 and 5", "Non-small Cell Lung Cancer", "Colorectal Cancer", "Bladder Cancer", "Gastric Cancer", "Biliary Cancer", "Cervical Cancer", "Endometrial Cancer", "Small Cell Lung Cancer Only in Module 5"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-09-21", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT04644068"
protocolSection.identificationModule.officialTitle: "A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies"
protocolSection.statusModule.overallStatus: "ACTIVE_NOT_RECRUITING"
protocolSection.designModule.phases: ["PHASE1", "PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Module 1: AZD5305 Monotherapy', 'Module 2: AZD5305 + Paclitaxel', 'Module 3: AZD5305 + Carboplatin with or without Paclitaxel', 'Module 4: AZD5305 + Trastuzumab Deruxtecan', 'Module 5 AZD5305 + Datopotamab Deruxtecan', 'Module 6 AZD5305 + Camizestrant'], 'description': 'Oral PARP inhibitor', 'name': 'AZD5305', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module 2: AZD5305 + Paclitaxel', 'Module 3: AZD5305 + Carboplatin with or without Paclitaxel'], 'description': 'IV Anti-microtubule agent', 'name': 'Paclitaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module 3: AZD5305 + Carboplatin with or without Paclitaxel'], 'description': 'IV Platinum chemotherapeutic', 'name': 'Carboplatin', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module 4: AZD5305 + Trastuzumab Deruxtecan'], 'description': 'IV Antibody-drug conjugate', 'name': 'T- Dxd', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module 5 AZD5305 + Datopotamab Deruxtecan'], 'description': 'IV Antibody-drug conjugate', 'name': 'Dato-DXd', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module 6 AZD5305 + Camizestrant'], 'description': 'Oral SERD Molecule', 'name': 'Camizestrant', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

A recorded drug name is not by itself an indication or a condition-specific relationship.

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