CLINICAL_TRIALS ClinicalTrials.gov record update

Phase 1b/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That Have Progressed Following Prior 177Lu-SSA Therapy

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT05477576
Title field or adapter rule: {'original_value': 'Phase 1b/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That Have Progressed Following Prior 177Lu-SSA Therapy', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:24.058772+00:00
Published At: 2026-10-05T00:00:00+00:00
Record Updated At: 2026-10-05
Source Retrieved At: 2026-10-31T22:17:54.613222+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["GEP-NET", "Gastroenteropancreatic Neuroendocrine Tumor", "Gastroenteropancreatic Neuroendocrine Tumor Disease", "Neuroendocrine Tumors", "Carcinoid", "Carcinoid Tumor", "Pancreatic NET"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-05", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT05477576"
protocolSection.identificationModule.officialTitle: "Phase 1b/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That Have Progressed Following Prior 177Lu-SSA Therapy"
protocolSection.statusModule.overallStatus: "ACTIVE_NOT_RECRUITING"
protocolSection.designModule.phases: ["PHASE3"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Phase 1b - RYZ101', 'Phase 3 - RYZ101', 'Phase 3 - RYZ101, PK/ECG Substudy adhoc subcohort'], 'description': 'RP3D as determined in Phase 1b', 'name': 'RYZ101', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Phase 3 - Standard of Care'], 'description': 'Everolimus', 'name': 'Everolimus', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Phase 3 - Standard of Care'], 'description': 'Sunitinib', 'name': 'Sunitinib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Phase 3 - Standard of Care'], 'description': 'High-dose octreotide', 'name': 'Octreotide', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Phase 3 - Standard of Care'], 'description': 'Lanreotide', 'name': 'Lanreotide', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

A recorded drug name is not by itself an indication or a condition-specific relationship.

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