Surgery Versus Stereotactic Ablative Radiotherapy for Patients With Locally Advanced Pancreatic Cancer With Favourable Biological Response Following Induction Chemotherapy (PREOPANC-4 RCT): An International Randomized Trial

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT07867873

Title field or adapter rule

{'original_value': 'Surgery Versus Stereotactic Ablative Radiotherapy for Patients With Locally Advanced Pancreatic Cancer With Favourable Biological Response Following Induction Chemotherapy (PREOPANC-4 RCT): An International Randomized Trial', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:23.746659+00:00

Published At

2026-10-09T00:00:00+00:00

Record Updated At

2026-10-09

Source Retrieved At

2026-10-31T22:17:52.415050+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Locally Advanced Pancreatic Carcinoma (LAPC)"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-09", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT07867873"

protocolSection.identificationModule.officialTitle

"Surgery Versus Stereotactic Ablative Radiotherapy for Patients With Locally Advanced Pancreatic Cancer With Favourable Biological Response Following Induction Chemotherapy (PREOPANC-4 RCT): An International Randomized Trial"

protocolSection.statusModule.overallStatus

"NOT_YET_RECRUITING"

protocolSection.designModule.phases

["PHASE3"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Locally Advanced Pancreatic Carcinoma (LAPC) (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Surgery'], 'description': 'Surgical exploration starts with a staging laparoscopy, unless already performed previsouly. Hereafter, exploration is typically performed via laparotomy. Although heterogeneity exist in surgical techniques, the following general surgical principles are considered state-of-the-art:\n\n1. Artery-first approach in case of potential arterial involvement\n2. Arterial divestment in case of radiological signs of (former) involvement without current signs of arterial wall ingrowth (and negative biopsy of peri-arterial tissue) during surgery to remove all (former) tumour tissue.\n3. In case of vascular reconstruction that requires a patch or interposition graft, an autol-ogous (e.g., veins, peritoneal / falciform patch, splenic artery) or biological (e.g., bovine patch) graft is strongly preferred over synthetic prosthesis', 'name': 'Pancreatic surgery', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['MRI guided stereotactic ablative radiotherapy'], 'description': "MRI-guided SABR must be initiated within four weeks after randomization and is delivered in a hypofractioned regimen of 50 Gy in five fractions of 10 Gy, prescribed to 95% of the planning target volume (PTV). Treatment will be administered on alternative days, two or three times per week, with an intended overall treatment duration of two weeks (i.e., 14 days). All patients will undergo an MR (and CT scan at the department's discretion) for radiotherapy planning. The gross tumour volume (GTV) will be defined based on those imaging datasets and the restaging imaging. A PTV margin of 3mm is applied.\n\nTwo MRI-guided SABR platforms are allowed. 1.5 Tesla MR-Linac and MRIdian system (0.35 Tesla MR-Linac). All patients will receive a proton pump inhibitor (oral) once daily during MRI-guided SABR, continued for three months afterwards to reduce gastrointestinal toxicity.", 'name': 'MRI guided stereotactic ablative radiotherapy', 'type': 'RADIATION'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

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