CLINICAL_TRIALS ClinicalTrials.gov record update

A Phase 1 Open-label Study to Investigate PF-08046876 in Adult Participants With Advanced Solid Tumors.

This page presents selected fields from the linked source record. It does not add a medical interpretation.

Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT07090499
Title field or adapter rule: {'original_value': 'A Phase 1 Open-label Study to Investigate PF-08046876 in Adult Participants With Advanced Solid Tumors.', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:23.623536+00:00
Published At: 2026-10-13T00:00:00+00:00
Record Updated At: 2026-10-13
Source Retrieved At: 2026-10-31T22:17:52.415050+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["Advanced/Metastatic Solid Tumors", "Bladder Cancer", "Urothelial Carcinoma", "Advanced Non-Small Cell Lung Cancer", "Carcinoma, Non Small Cell Lung", "Carcinoma, Squamous Cell of Head and Neck", "Head and Neck Cancer", "Esophageal Cancer", "Gastroesophageal Junction Adenocarcinoma", "Esophageal Squamous Cell Carcinoma", "Esophageal Adenocarcinoma", "Pancreatic Adenocarcinoma", "Pancreatic Cancer"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-13", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT07090499"
protocolSection.identificationModule.officialTitle: "A Phase 1 Open-label Study to Investigate PF-08046876 in Adult Participants With Advanced Solid Tumors."
protocolSection.statusModule.overallStatus: "RECRUITING"
protocolSection.designModule.phases: ["PHASE1"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Part 1 Dose Escalation', 'Part 2 Dose Expansion', 'Part 2 Dose Optimization', 'Part 3 - Combination Cohort 1', 'Part 3 - Combination Cohort 2', 'Part 3 - Combination Cohort 3', 'Part 3 - Combination Cohort 4', 'Part 3 - Combination Cohort 5'], 'description': 'Intravenous administration', 'name': 'PF-08046876', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 3 - Combination Cohort 1', 'Part 3 - Combination Cohort 2', 'Part 3 - Combination Cohort 5'], 'description': 'Intravenous administration', 'name': 'Pembrolizumab', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 3 - Combination Cohort 3'], 'description': 'Intravenous administration', 'name': 'Cisplatin', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Part 3 - Combination Cohort 2', 'Part 3 - Combination Cohort 4'], 'description': 'Intravenous administration', 'name': 'Carboplatin', 'type': 'COMBINATION_PRODUCT'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.