A Phase Ib, Multicenter, Randomized Study Evaluating the Safety and Activity of GDC-7035 With Anti-Cancer Therapies as First-Line Treatment in Patients With KRAS G12D-Mutated Unresectable Advanced or Metastatic Colorectal Cancer or Pancreatic Ductal Adenocarcinoma

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT07859085

Title field or adapter rule

{'original_value': 'A Phase Ib, Multicenter, Randomized Study Evaluating the Safety and Activity of GDC-7035 With Anti-Cancer Therapies as First-Line Treatment in Patients With KRAS G12D-Mutated Unresectable Advanced or Metastatic Colorectal Cancer or Pancreatic Ductal Adenocarcinoma', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:23.616898+00:00

Published At

2026-10-13T00:00:00+00:00

Record Updated At

2026-10-13

Source Retrieved At

2026-10-31T22:17:52.415050+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Colorectal Neoplasms", "Pancreatic Ductal Adenocarcinoma"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-13", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT07859085"

protocolSection.identificationModule.officialTitle

"A Phase Ib, Multicenter, Randomized Study Evaluating the Safety and Activity of GDC-7035 With Anti-Cancer Therapies as First-Line Treatment in Patients With KRAS G12D-Mutated Unresectable Advanced or Metastatic Colorectal Cancer or Pancreatic Ductal Adenocarcinoma"

protocolSection.statusModule.overallStatus

"NOT_YET_RECRUITING"

protocolSection.designModule.phases

["PHASE1"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Colorectal Neoplasms (protocolSection.conditionsModule.conditions)
• Pancreatic Ductal Adenocarcinoma (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Group A: GDC-7035 + mFOLFOX6 + Panitumumab', 'Group B: GDC-7035 + FOLFIRI + Panitumumab', 'Group C: GDC-7035 + mFOLFIRINOX or GDC-7035 Monotherapy', 'Group D: GDC-7035 + Gem-nabP or GDC-7035 Monotherapy'], 'description': 'Participants will receive GDC-7035 as per the schedule specified in the protocol.', 'name': 'GDC-7035', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Group A: GDC-7035 + mFOLFOX6 + Panitumumab', 'Group B: GDC-7035 + FOLFIRI + Panitumumab'], 'description': 'Participants will receive panitumumab in accordance with the local prescribing information.', 'name': 'Panitumumab', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Group A: GDC-7035 + mFOLFOX6 + Panitumumab'], 'description': 'Participants will receive mFOLFOX6 in accordance with the local prescribing information.', 'name': 'mFOLFOX6', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Group B: GDC-7035 + FOLFIRI + Panitumumab'], 'description': 'Participants will receive FOLFIRI in accordance with the local prescribing information.', 'name': 'FOLFIRI', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Group C: GDC-7035 + mFOLFIRINOX or GDC-7035 Monotherapy'], 'description': 'Participants will receive mFOLFIRINOX in accordance with the local prescribing information.', 'name': 'mFOLFIRINOX', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Group D: GDC-7035 + Gem-nabP or GDC-7035 Monotherapy'], 'description': 'Participants will receive Gem-nabP in accordance with the local prescribing information.', 'name': 'Gem-nabP', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• GDC-7035 (protocolSection.armsInterventionsModule.interventions[].name)
• mFOLFOX6 (protocolSection.armsInterventionsModule.interventions[].name)
• FOLFIRI (protocolSection.armsInterventionsModule.interventions[].name)
• mFOLFIRINOX (protocolSection.armsInterventionsModule.interventions[].name)
• Gem-nabP (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.