A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT04172532

Title field or adapter rule

{'original_value': 'A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:23.003080+00:00

Published At

2026-10-20T00:00:00+00:00

Record Updated At

2026-10-20

Source Retrieved At

2026-10-31T22:17:52.415050+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Locally Advanced Pancreatic Adenocarcinoma", "Stage III Pancreatic Cancer AJCC v8"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-20", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT04172532"

protocolSection.identificationModule.officialTitle

"A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma"

protocolSection.statusModule.overallStatus

"SUSPENDED"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Locally Advanced Pancreatic Adenocarcinoma (protocolSection.conditionsModule.conditions)
• Stage III Pancreatic Cancer AJCC v8 (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Phase I (hypofractionated radiation therapy, M3814)', 'Phase II Group I (hypofractionated radiation therapy M3814)', 'Phase II Group II(hypofractionated radiation therapy, placebo)'], 'description': 'Undergo tissue collection', 'name': 'Biopsy Procedure', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (hypofractionated radiation therapy, M3814)', 'Phase II Group I (hypofractionated radiation therapy M3814)', 'Phase II Group II(hypofractionated radiation therapy, placebo)'], 'description': 'Undergo blood sample collection', 'name': 'Biospecimen Collection', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (hypofractionated radiation therapy, M3814)', 'Phase II Group I (hypofractionated radiation therapy M3814)', 'Phase II Group II(hypofractionated radiation therapy, placebo)'], 'description': 'Undergo CT', 'name': 'Computed Tomography', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (hypofractionated radiation therapy, M3814)', 'Phase II Group I (hypofractionated radiation therapy M3814)', 'Phase II Group II(hypofractionated radiation therapy, placebo)'], 'description': 'Undergo hypofractionated radiation therapy', 'name': 'Hypofractionated Radiation Therapy', 'type': 'RADIATION'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (hypofractionated radiation therapy, M3814)', 'Phase II Group I (hypofractionated radiation therapy M3814)', 'Phase II Group II(hypofractionated radiation therapy, placebo)'], 'description': 'Undergo MRI', 'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase I (hypofractionated radiation therapy, M3814)', 'Phase II Group I (hypofractionated radiation therapy M3814)'], 'description': 'Given PO', 'name': 'Peposertib', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Phase II Group II(hypofractionated radiation therapy, placebo)'], 'description': 'Given PO', 'name': 'Placebo Administration', 'type': 'OTHER'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• Peposertib (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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