CLINICAL_TRIALS ClinicalTrials.gov record update

A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability & Antitumor Activity of TNG462 in Combination With Other Agents in Patients With Pancreatic Cancer With MTAP Loss and Pancreatic or Non-Small Cell Lung Cancer With MTAP Loss & RAS Mutation

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT06922591
Title field or adapter rule: {'original_value': 'A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability & Antitumor Activity of TNG462 in Combination With Other Agents in Patients With Pancreatic Cancer With MTAP Loss and Pancreatic or Non-Small Cell Lung Cancer With MTAP Loss & RAS Mutation', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:22.423613+00:00
Published At: 2026-10-23T00:00:00+00:00
Record Updated At: 2026-10-23
Source Retrieved At: 2026-10-31T22:17:25.750886+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["PDAC", "PDAC - Pancreatic Ductal Adenocarcinoma", "NSCLC", "RAS Mutation", "MTAP Deletion", "Lung Cancer", "Pancreatic Cancer Metastatic", "Thoracic Cancer"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-23", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT06922591"
protocolSection.identificationModule.officialTitle: "A Phase 1/2, Multicenter, Open-Label Study to Evaluate Safety, Tolerability \u0026 Antitumor Activity of TNG462 in Combination With Other Agents in Patients With Pancreatic Cancer With MTAP Loss and Pancreatic or Non-Small Cell Lung Cancer With MTAP Loss \u0026 RAS Mutation"
protocolSection.statusModule.overallStatus: "RECRUITING"
protocolSection.designModule.phases: ["PHASE1", "PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Dose Escalation 1A', 'Dose Expansion 2A', 'Dose Expansion 2B', 'Dose escalation 1B', 'Experimental: Dose Escalation 1C', 'Experimental: Dose Escalation 1D', 'Experimental: Dose Expansion 2C', 'Experimental: Dose Expansion 2D'], 'description': 'MTA cooperative PRMT5 inhibitor', 'name': 'TNG462', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose Expansion 2B', 'Dose escalation 1B'], 'description': 'RAS(ON) G12D selective covalent inhibitor', 'name': 'RMC-9805', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Dose Escalation 1A', 'Dose Expansion 2A'], 'description': 'RAS(ON) multi-selective inhibitor', 'name': 'RMC-6236', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Experimental: Dose Escalation 1C', 'Experimental: Dose Expansion 2C'], 'description': 'Chemotherapy', 'name': 'mFOLFIRINOX', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Experimental: Dose Escalation 1D', 'Experimental: Dose Expansion 2D'], 'description': 'Chemotherapy', 'name': 'gemcitabine/nab-paclitaxel', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

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