CLINICAL_TRIALS ClinicalTrials.gov record update

A Phase 1/1b First-in-Human, Open Label, Dose Escalation and Cohort Expansion Study of MGC026 in Participants With Advanced Solid Tumors

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Record identity and dates

Source: ClinicalTrials.gov
Source record ID: NCT06242470
Title field or adapter rule: {'original_value': 'A Phase 1/1b First-in-Human, Open Label, Dose Escalation and Cohort Expansion Study of MGC026 in Participants With Advanced Solid Tumors', 'source_field': 'protocolSection.identificationModule.officialTitle'}
Ingested At: 2026-10-31T23:27:21.727702+00:00
Published At: 2026-10-28T00:00:00+00:00
Record Updated At: 2026-10-28
Source Retrieved At: 2026-10-31T22:19:02.163121+00:00
Timestamp Basis: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter
Date limitation: ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

protocolSection.conditionsModule.conditions: ["Advanced Solid Tumor", "Advanced Cancer", "Metastatic Cancer", "Squamous Cell Carcinoma of Head and Neck", "Non Small Cell Lung Cancer", "Small-cell Lung Cancer", "Bladder Cancer", "Sarcoma", "Endometrial Cancer", "Melanoma", "Castration Resistant Prostatic Cancer", "Cervical Cancer", "Colorectal Cancer", "Gastric Cancer", "Gastro-esophageal Cancer", "Pancreas Cancer", "Clear Cell Renal Cell Carcinoma", "Hepatocellular Carcinoma", "Platinum-resistant Ovarian Cancer", "Breast Cancer", "Ovarian Cancer", "Esophageal Squamous Cell Cancer (SCC)"]
protocolSection.statusModule.lastUpdatePostDateStruct: {"date": "2026-10-28", "type": "ACTUAL"}
protocolSection.identificationModule.nctId: "NCT06242470"
protocolSection.identificationModule.officialTitle: "A Phase 1/1b First-in-Human, Open Label, Dose Escalation and Cohort Expansion Study of MGC026 in Participants With Advanced Solid Tumors"
protocolSection.statusModule.overallStatus: "RECRUITING"
protocolSection.designModule.phases: ["PHASE1"]
protocolSection.statusModule.resultsFirstPostDateStruct: null

{'armGroupLabels': ['Module A Cohort 1', 'Module A Cohort 2', 'Module A Cohort 3', 'Module A Cohort 4', 'Module A Cohort 5', 'Module A Cohort 6'], 'description': 'Escalating doses of MGC026', 'name': 'MGC026 Dose Escalation', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module A Expansion Cohort 5', 'Module A Expansion Cohort 6', 'Module A Expansion Cohort 7', 'Module A Expansion Cohort 8', 'Module A Expansion cohort 1', 'Module A Expansion cohort 2', 'Module A Expansion cohort 3', 'Module A Expansion cohort 4', 'Module B Part 1, Dose Level 2'], 'description': 'MGC026 recommended dose for expansion', 'name': 'MGC026 Dose for Expansion', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module B Part 1, Dose Level 1', 'Module B Part 1, Dose Level 2'], 'description': '200 mg, IV, every 3 weeks.', 'name': 'Pembrollizumab', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])
{'armGroupLabels': ['Module B Part 1, Dose Level 1'], 'description': 'less than RDE dose level, IV, every 3 weeks', 'name': 'vobramitamab tavatecan', 'type': 'BIOLOGICAL'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

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