A Phase I/IIa Image-Guided, Alpha-Particle Therapy Study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in Patients With Solid Tumors That Are Known to be Fibroblast Activation Protein (FAP)-Positive

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT06710756

Title field or adapter rule

{'original_value': 'A Phase I/IIa Image-Guided, Alpha-Particle Therapy Study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in Patients With Solid Tumors That Are Known to be Fibroblast Activation Protein (FAP)-Positive', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-31T23:27:21.703252+00:00

Published At

2026-10-28T00:00:00+00:00

Record Updated At

2026-10-28

Source Retrieved At

2026-10-31T22:18:28.651351+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Pancreatic Ductal Adenocarcinoma", "Gastric Cancer", "Esophageal Cancer", "Colorectal Cancer", "Ovarian Cancer", "Head and Neck Cancer", "Sarcoma", "Mesothelioma"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-28", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT06710756"

protocolSection.identificationModule.officialTitle

"A Phase I/IIa Image-Guided, Alpha-Particle Therapy Study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in Patients With Solid Tumors That Are Known to be Fibroblast Activation Protein (FAP)-Positive"

protocolSection.statusModule.overallStatus

"RECRUITING"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

null

Study condition terms

• Pancreatic Ductal Adenocarcinoma (protocolSection.conditionsModule.conditions)
• Gastric Cancer (protocolSection.conditionsModule.conditions)
• Esophageal Cancer (protocolSection.conditionsModule.conditions)
• Colorectal Cancer (protocolSection.conditionsModule.conditions)
• Ovarian Cancer (protocolSection.conditionsModule.conditions)
• Head and Neck Cancer (protocolSection.conditionsModule.conditions)
• Sarcoma (protocolSection.conditionsModule.conditions)
• Mesothelioma (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Dose Escalation', 'Dose Expansion'], 'description': '\\[203Pb\\]Pb-PSV359 is administered by intravenous bolus injection for single-photon emission computed tomography imaging.', 'name': '[203Pb]Pb-PSV359', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Dose Escalation', 'Dose Expansion'], 'description': '\\[212Pb\\]Pb-PSV359 is administered by intravenous infusion for treatment of FAP expressing cancers.', 'name': '[212Pb]Pb-PSV359', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• [203Pb]Pb-PSV359 (protocolSection.armsInterventionsModule.interventions[].name)
• [212Pb]Pb-PSV359 (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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