A Feasibility and Pilot Study of Combined Treatment Protocol Using Aerobic Exercise and Duloxetine in Older Adults With Symptomatic Knee Osteoarthritis and Comorbid Depression

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT04111627

Title field or adapter rule

{'original_value': 'A Feasibility and Pilot Study of Combined Treatment Protocol Using Aerobic Exercise and Duloxetine in Older Adults With Symptomatic Knee Osteoarthritis and Comorbid Depression', 'source_field': 'protocolSection.identificationModule.officialTitle'}

Ingested At

2026-10-30T23:06:05.378172+00:00

Published At

2026-10-29T00:00:00+00:00

Record Updated At

2026-10-29

Results Posted At

2026-10-29

Source Retrieved At

2026-10-30T22:08:17.017215+00:00

Timestamp Basis

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Date limitation

ClinicalTrials.gov API/RSS response retrieval timestamp recorded by Dossier adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Knee Osteoarthritis", "Depression"]

protocolSection.statusModule.lastUpdatePostDateStruct

{"date": "2026-10-29", "type": "ACTUAL"}

protocolSection.identificationModule.nctId

"NCT04111627"

protocolSection.identificationModule.officialTitle

"A Feasibility and Pilot Study of Combined Treatment Protocol Using Aerobic Exercise and Duloxetine in Older Adults With Symptomatic Knee Osteoarthritis and Comorbid Depression"

protocolSection.statusModule.overallStatus

"COMPLETED"

protocolSection.designModule.phases

["PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct

{"date": "2026-10-29", "type": "ACTUAL"}

Study condition terms

• Knee Osteoarthritis (protocolSection.conditionsModule.conditions)
• Depression (protocolSection.conditionsModule.conditions)

Interventions recorded in this study

• {'armGroupLabels': ['Aerobic exercise plus Duloxetine'], 'description': 'Participants with symptomatic knee osteoarthritis and depressive symptoms will be enrolled in a progressive walking program designed to reduce pain and disability and improve psychosocial health.', 'name': 'Aerobic exercise', 'type': 'BEHAVIORAL'} (protocolSection.armsInterventionsModule.interventions[])
• {'armGroupLabels': ['Aerobic exercise plus Duloxetine'], 'description': 'Duloxetine is an FDA-approved selective serotonin and norepinephrine reuptake inhibitor antidepressant approved for the treatment of neuropathic pain in symptomatic knee osteoarthritis as well as depression in adults. Participants with symptomatic knee osteoarthritis and depressive symptoms will receive duloxetine to decrease pain and depression severity to enhance their ability to engage in aerobic exercise.', 'name': 'Duloxetine', 'type': 'DRUG'} (protocolSection.armsInterventionsModule.interventions[])

An intervention appearing in a study record does not establish an effect or an approved use.

Drug names recorded in this source

• Duloxetine (protocolSection.armsInterventionsModule.interventions[].name)

A recorded drug name is not by itself an indication or a condition-specific relationship.

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