Open-Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Efficacy of EDIT-101 in Adult and Pediatric Participants With Leber Congenital Amaurosis Type 10 (LCA10), With Centrosomal Protein 290 (CEP290)-Related Retinal Degeneration Caused by a Compound Heterozygous or Homozygous Mutation Involving c.2991+1655A>G in Intron 26 (IVS26) of the CEP290 Gene ("LCA10-IVS26")

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Record identity and dates

Source

ClinicalTrials.gov

Source record ID

NCT03872479

Title field or adapter rule

protocolSection.identificationModule.officialTitle

Ingested At

2026-04-28T10:38:53.127880+00:00

Published At

2022-12-05T00:00:00+00:00

Record Updated At

2022-12-05

Timestamp Basis

source retrieval time was not retained by the feed adapter

Date limitation

source retrieval time was not retained by the feed adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions

["Leber Congenital Amaurosis 10", "Inherited Retinal Dystrophies", "Eye Diseases, Hereditary", "Retinal Disease", "Retinal Degeneration", "Vision Disorders", "Eye Disorders Congenital"]

protocolSection.statusModule.lastUpdatePostDateStruct.date

"2022-12-05"

protocolSection.identificationModule.nctId

"NCT03872479"

protocolSection.identificationModule.officialTitle

"Open-Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Efficacy of EDIT-101 in Adult and Pediatric Participants With Leber Congenital Amaurosis Type 10 (LCA10), With Centrosomal Protein 290 (CEP290)-Related Retinal Degeneration Caused by a Compound Heterozygous or Homozygous Mutation Involving c.2991+1655A\u003eG in Intron 26 (IVS26) of the CEP290 Gene (\"LCA10-IVS26\")"

protocolSection.statusModule.overallStatus

"UNKNOWN"

protocolSection.designModule.phases

["PHASE1", "PHASE2"]

protocolSection.statusModule.resultsFirstPostDateStruct.date

""

Study condition terms

• Leber Congenital Amaurosis 10 (protocolSection.conditionsModule.conditions)
• Inherited Retinal Dystrophies (protocolSection.conditionsModule.conditions)
• Eye Diseases, Hereditary (protocolSection.conditionsModule.conditions)
• Retinal Disease (protocolSection.conditionsModule.conditions)
• Retinal Degeneration (protocolSection.conditionsModule.conditions)
• Vision Disorders (protocolSection.conditionsModule.conditions)
• Eye Disorders Congenital (protocolSection.conditionsModule.conditions)

Intervention details are not present in the imported fields for this record. No drug-condition relationship is inferred from co-listing.

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