Clinical Trial Update: Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Total Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome [Phase 2]

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Summary

Phase 2 clinical trial evaluating a combined regimen including iodine-131 monoclonal antibody BC8, fludarabine phosphate, total body irradiation, and donor stem…

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Diseases / indications

• Acute Myeloid Leukemia
• Anemia with Excess Blasts
• Anemia with Ringed Sideroblasts
• Cytopenia with Multilineage Dysplasia
• Myelodysplastic Syndrome
• Myelodysplastic Syndromes
• Myelomonocytic Leukemia

Drugs mentioned

• CYCLOSPORINE (cyclosporine)
• Donor stem cell transplant
• Fludarabine phosphate (Fludarabine phosphate)
• MYCOPHENOLATE MOFETIL (MYCOPHENOLATE MOFETIL)
• Total Body Irradiation
• iodine-131 monoclonal antibody BC8 (iodine-131 labeled monoclonal antibody BC8)

Snippet

Sponsor: Fred Hutchinson Cancer Center | Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Status: TERMINATED | Results posted: 2022-08-01