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EMA guidance · 2025-01-30

One Health: EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi

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Summary

EU health and environment agencies warn that agricultural use of azole fungicides may drive resistance in Aspergillus fungi, potentially reducing the effectiven…

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Diseases / indications

Drugs mentioned

  • Cresemba (isavuconazole)
  • NOXAFIL (POSACONAZOLE)
  • SPORANOX (Itraconazole)
  • VFEND (Voriconazole)

Snippet

The extensive use of azole fungicides (azoles), particularly in some agricultural and horticultural practices, can increase the risk of Aspergillus fungi developing resistance to essential antifungal treatments. This significant finding is highlighted in a report by the five EU health and environment agencies, with support from the European Commission’s Joint Research Centre (JRC). The Agencies collaborated under a One Health approach to address this growing threat.