Clinical Trial Update: Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer [Phase 2]

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Summary

A Phase 2 trial of metformin hydrochloride and doxycycline in localized breast or uterine cancers was terminated, with results posted.

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Diseases / indications

• Breast Carcinoma
• Endometrial Clear Cell Adenocarcinoma
• Endometrial Serous Adenocarcinoma
• Uterine Corpus Cancer
• Uterine Corpus Carcinosarcoma

Drugs mentioned

• Doxycycline (Doxycycline)
• METFORMIN HYDROCHLORIDE (Metformin hydrochloride)

Snippet

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Conditions: Breast Carcinoma, Endometrial Clear Cell Adenocarcinoma | Phase 2 | Status: TERMINATED | Results posted: 2026-04-22