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A Randomized Phase 2 Study of CDX-1127 (Varlilumab) in Combination With Nivolumab in Patients With Relapsed or Refractory Aggressive B-cell Lymphomas

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Record identity and dates

Source
ClinicalTrials.gov
Source record ID
NCT03038672
Title field or adapter rule
protocolSection.identificationModule.officialTitle
Ingested At
2026-04-25T22:29:00.195602+00:00
Published At
2024-10-16T00:00:00+00:00
Record Updated At
2025-11-10
Results Posted At
2024-10-16
Timestamp Basis
source retrieval time was not retained by the feed adapter
Date limitation
source retrieval time was not retained by the feed adapter

Fields recorded by this source

protocolSection.conditionsModule.conditions
["ALK-Positive Large B-Cell Lymphoma", "Diffuse Large B-Cell Lymphoma Activated B-Cell Type", "Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation", "Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type", "Diffuse Large B-Cell Lymphoma, Not Otherwise Specified", "EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified", "EBV-Positive Mucocutaneous Ulcer", "HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified", "High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements", "High Grade B-Cell Lymphoma, Not Otherwise Specified", "Intravascular Large B-Cell Lymphoma", "Large B-Cell Lymphoma With 11q Aberration", "Large B-Cell Lymphoma With IRF4 Rearrangement", "Plasmablastic Lymphoma", "Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System", "Primary Effusion Lymphoma", "Recurrent B-Cell Non-Hodgkin Lymphoma", "Recurrent Burkitt Lymphoma", "Recurrent Diffuse Large B-Cell Lymphoma", "Recurrent Gray-Zone Lymphoma", "Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements", "Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements", "Recurrent Lymphomatoid Granulomatosis", "Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type", "Recurrent Primary Mediastinal Large B-Cell Lymphoma", "Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma", "Refractory B-Cell Non-Hodgkin Lymphoma", "Refractory Burkitt Lymphoma", "Refractory Diffuse Large B-Cell Lymphoma", "Refractory Gray-Zone Lymphoma", "Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements", "Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements", "Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type", "Refractory Primary Mediastinal Large B-Cell Lymphoma", "Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma"]
protocolSection.statusModule.lastUpdatePostDateStruct.date
"2025-11-10"
protocolSection.identificationModule.nctId
"NCT03038672"
protocolSection.identificationModule.officialTitle
"A Randomized Phase 2 Study of CDX-1127 (Varlilumab) in Combination With Nivolumab in Patients With Relapsed or Refractory Aggressive B-cell Lymphomas"
protocolSection.statusModule.overallStatus
"ACTIVE_NOT_RECRUITING"
protocolSection.designModule.phases
["PHASE2"]
protocolSection.statusModule.resultsFirstPostDateStruct.date
"2024-10-16"

Study condition terms

  • ALK-Positive Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Diffuse Large B-Cell Lymphoma Activated B-Cell Type (protocolSection.conditionsModule.conditions)
  • Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation (protocolSection.conditionsModule.conditions)
  • Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type (protocolSection.conditionsModule.conditions)
  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (protocolSection.conditionsModule.conditions)
  • EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (protocolSection.conditionsModule.conditions)
  • EBV-Positive Mucocutaneous Ulcer (protocolSection.conditionsModule.conditions)
  • HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (protocolSection.conditionsModule.conditions)
  • High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements (protocolSection.conditionsModule.conditions)
  • High Grade B-Cell Lymphoma, Not Otherwise Specified (protocolSection.conditionsModule.conditions)
  • Intravascular Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Large B-Cell Lymphoma With 11q Aberration (protocolSection.conditionsModule.conditions)
  • Large B-Cell Lymphoma With IRF4 Rearrangement (protocolSection.conditionsModule.conditions)
  • Plasmablastic Lymphoma (protocolSection.conditionsModule.conditions)
  • Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System (protocolSection.conditionsModule.conditions)
  • Primary Effusion Lymphoma (protocolSection.conditionsModule.conditions)
  • Recurrent B-Cell Non-Hodgkin Lymphoma (protocolSection.conditionsModule.conditions)
  • Recurrent Burkitt Lymphoma (protocolSection.conditionsModule.conditions)
  • Recurrent Diffuse Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Recurrent Gray-Zone Lymphoma (protocolSection.conditionsModule.conditions)
  • Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements (protocolSection.conditionsModule.conditions)
  • Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements (protocolSection.conditionsModule.conditions)
  • Recurrent Lymphomatoid Granulomatosis (protocolSection.conditionsModule.conditions)
  • Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type (protocolSection.conditionsModule.conditions)
  • Recurrent Primary Mediastinal Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Refractory B-Cell Non-Hodgkin Lymphoma (protocolSection.conditionsModule.conditions)
  • Refractory Burkitt Lymphoma (protocolSection.conditionsModule.conditions)
  • Refractory Diffuse Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Refractory Gray-Zone Lymphoma (protocolSection.conditionsModule.conditions)
  • Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements (protocolSection.conditionsModule.conditions)
  • Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements (protocolSection.conditionsModule.conditions)
  • Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type (protocolSection.conditionsModule.conditions)
  • Refractory Primary Mediastinal Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)
  • Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (protocolSection.conditionsModule.conditions)

Intervention details are not present in the imported fields for this record. No drug-condition relationship is inferred from co-listing.

This index keeps the source fields it imported; it may not contain the complete original record. Verify wording and context in the linked source.