Clinical Trial Update: LIONS (PLK4 Inhibitor in Advanced Solid Tumors) [Phase 1]

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Summary

An early-phase (Phase 1) trial of an investigational PLK4 inhibitor in patients with advanced solid tumors was terminated; results were posted on 2025-11-21.

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Diseases / indications

• Solid Tumors

Drugs mentioned

• PLK4 inhibitor (investigational) (Polo-like kinase 4 inhibitor)

Snippet

Sponsor: Repare Therapeutics | Conditions: Advanced Solid Tumor | Phase 1 | Status: TERMINATED | Results posted: 2025-11-21