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CLINICAL_TRIALS research · 2026-01-23

Clinical Trial Update: Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer [Phase 1]

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Summary

A Phase 1 clinical trial evaluating Ivonescimab and ADG126, alone and in combination with leucovorin plus fluorouracil or FOLFIRI, for advanced or metastatic mi…

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Diseases / indications

Drugs mentioned

  • ADG126
  • FLUOROURACIL (Fluorouracil)
  • FOLFIRI regimen (irinotecan + leucovorin + 5-fluorouracil)
  • Ivonescimab (AK112/SMT112)
  • Leucovorin (folinic acid)

Snippet

Sponsor: City of Hope Medical Center | Conditions: Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Status: NOT_YET_RECRUITING