Clinical Trial Update: Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma [Phase 2]

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Summary

A Phase 2 clinical trial evaluating metformin hydrochloride in combination with doxycycline for head and neck squamous cell carcinoma has been terminated, with …

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Diseases / indications

• Head and Neck Squamous Cell Carcinoma
• Laryngeal Cancer
• Lip Cancer
• Oral Cavity Cancer
• Pharyngeal Cancer

Drugs mentioned

• Doxycycline (Doxycycline)
• METFORMIN HYDROCHLORIDE (Metformin hydrochloride)

Snippet

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Conditions: Larynx, LIP | Phase 2 | Status: TERMINATED | Results posted: 2026-01-29