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CLINICAL_TRIALS research · 2026-04-13

Clinical Trial Update: Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial [Phase 2]

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Summary

Phase 2 study of M1774 (tuvusertib) in combination with avelumab for Merkel cell carcinoma; currently active but not recruiting.

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Diseases / indications

Drugs mentioned

  • Avelumab (avelumab)
  • M1774 (tuvusertib) (tuvusertib)

Snippet

Sponsor: National Cancer Institute (NCI) | Conditions: Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Status: ACTIVE_NOT_RECRUITING