Type 2 Diabetes Mellitus

CLINICAL_TRIALS research · 2025-11-25

Clinical Trial Update: A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Type 2 Diabetes Mellitus Subjects (T2DM) Treated With Basal + Prandial Insulin [Phase 3]

This is a Phase 3 trial update on the efficacy and safety of GZR4 in adults with type 2 diabetes mellitus treated with basal plus prandial i…

CLINICAL_TRIALS trial_result · 2025-11-25

Clinical Trial Update: A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes [Phase 2]

Phase 2 study evaluating retatrutide's effects on renal function in adults with overweight/obesity and chronic kidney disease, with or witho…

CLINICAL_TRIALS trial_result · 2025-11-25

Clinical Trial Update: The Efficacy and Safety of Empagliflozin - Linagliptin and Empagliflozin- Metformin Therapy in Reduction of Body Weight in Type 2 Diabetic Patients . [Phase 4]

A completed Phase 4 trial evaluated the efficacy and safety of empagliflozin combined with linagliptin versus empagliflozin combined with me…

CLINICAL_TRIALS research · 2025-11-25

Clinical Trial Update: A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Subjects With Type 2 Diabetes Mellitus and Poor Blood Glucose Control by Diet and Exercise [Phase 3]

A Phase III trial update on the efficacy and safety of GZR18 Injection in adults with Type 2 Diabetes Mellitus and poor glycemic control, cu…

CLINICAL_TRIALS research · 2025-11-25

Clinical Trial Update: A Study of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus (T2DM) [Phase 2]

Amgen is conducting a Phase 2 study of Maridebart Cafraglutide in adults with Type 2 Diabetes Mellitus. The trial status is Active Not Recru…

CLINICAL_TRIALS other · 2025-11-25

Clinical Trial Update: A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus [Phase 3]

Phase III clinical trial evaluating the efficacy and safety of GZR18 injection in adults with Type 2 Diabetes Mellitus; the study is current…

CLINICAL_TRIALS research · 2025-11-25

Clinical Trial Update: A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE) [Phase 3]

A Phase 3 trial update (SUSTAIN OPTIMIZE) has completed and compared semaglutide with a lower-dose insulin glargine regimen versus a higher-…

CLINICAL_TRIALS research · 2025-11-25

Clinical Trial Update: A Phase IIIb Clinical Study to Assess the Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin [Phase 3]

This document reports a Phase 3b clinical trial evaluating GZR4 for efficacy and safety in adults with type 2 diabetes mellitus who are trea…

CLINICAL_TRIALS trial_result · 2025-11-25

Clinical Trial Update: A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) [Phase 4]

REALYSE is a Phase 4 trial comparing RYBELSUS to other glucose-lowering tablets in adults with Type 2 diabetes. The study status is COMPLETE…

CLINICAL_TRIALS trial_result · 2025-11-24

Clinical Trial Update: Efficacy and Safety of SHR-3167 and Insulin Glargine in Type 2 Diabetes Subjects [Phase 2]

Phase 2 trial evaluating the efficacy and safety of SHR-3167 in combination with insulin glargine in adults with type 2 diabetes.

CLINICAL_TRIALS research · 2025-11-24

Clinical Trial Update: HF Prevalence and Evolution of HF in DM II Patients at High Risk

AstraZeneca-sponsored registry study assessing the prevalence and progression of heart failure in high-risk patients with type 2 diabetes me…

CLINICAL_TRIALS research · 2025-11-24

Clinical Trial Update: A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE [NA]

Clinical trial update for a randomized controlled study of postpartum diabetes screening (DIP) and follow-up care (PP CARE), currently recru…

CLINICAL_TRIALS trial_result · 2025-11-24

Clinical Trial Update: PROmoting Diabetes Education and Management Through Peer Support and Team Referral [NA]

This clinical trial update notes the completion of a study evaluating a peer-support and team-referral program to promote diabetes education…

CLINICAL_TRIALS research · 2025-11-24

Clinical Trial Update: PDE3B in Metabolic Regulation

A clinical trial update indicates a study evaluating PDE3B in metabolic regulation is currently enrolling by invitation, focusing on type 2 …

CLINICAL_TRIALS trial_result · 2025-11-24

Clinical Trial Update: Efficacy of Educational Nutrition and Exercise on the Regulation of Appetite Through Exosomes in Type 2 Diabetics [NA]

This clinical trial update discusses the efficacy of an educational nutrition and exercise program on regulating appetite through exosomes i…

CLINICAL_TRIALS trial_result · 2025-11-24

Clinical Trial Update: Umbilical Cord Mesenchymal Stem Cell Secretome Administration in Severe Erectile Dysfunction Non-responsive to Sildenafil [NA]

A completed clinical trial evaluating the use of umbilical cord mesenchymal stem cell secretome for severe erectile dysfunction non-responsi…

CLINICAL_TRIALS research · 2025-11-24

Clinical Trial Update: Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control [Phase 4]

Phase 4 clinical trial (recruiting) evaluating the efficacy and safety of a metformin plus SGLT-2 inhibitor plus GLP-1 receptor agonist comb…

EMA approval · 2025-11-21

EMA Authorised: Steglujan (ertugliflozin l-pyroglutamic acid;sitagliptin phosphate monohydrate) — Merck Sharp & Dohme B.V.

EMA authorised Steglujan, a fixed-dose combination tablet of ertugliflozin and sitagliptin, for type 2 diabetes mellitus in the EU, issued t…

EMA approval · 2025-11-21

EMA Authorised: Segluromet (ertugliflozin l-pyroglutamic acid;metformin hydrochloride) — Merck Sharp & Dohme B.V.

The EMA authorised Segluromet, a fixed-dose combination of ertugliflozin and metformin, for the treatment of type 2 diabetes in adults.

CLINICAL_TRIALS trial_result · 2025-11-21

Clinical Trial Update: Comparison of Type 2 Diabetes Pharmacotherapy Regimens

A Kaiser Permanente-sponsored trial comparing pharmacotherapy regimens for type 2 diabetes has completed, and results have been posted.

CLINICAL_TRIALS trial_result · 2025-11-21

Clinical Trial Update: Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of CT-L03 in Healthy Volunteers [Phase 1]

Phase I pharmacokinetic and safety study in healthy volunteers evaluating co-administration of L03RD1 and L03RD2 or CT-L03; study completed.

CLINICAL_TRIALS research · 2025-11-21

Clinical Trial Update: DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes [Phase 3]

Phase 3 clinical trial evaluating a DPP-4 inhibitor to treat post-stroke cognitive impairment in patients with ischemic stroke and type 2 di…

CLINICAL_TRIALS trial_result · 2025-11-21

Clinical Trial Update: The Breakfast Study [Phase 1, Phase 2]

A Phase 1/2 clinical trial sponsored by the University of Michigan for Type 2 diabetes mellitus has completed.

CLINICAL_TRIALS research · 2025-11-21

Clinical Trial Update: WhatsApp-Based and Family-Involved Diabetes Self-Management Education Study [NA]

Clinical trial update from Koç University on a WhatsApp-based, family-involved diabetes self-management education study; the trial is not ye…

CLINICAL_TRIALS trial_result · 2025-11-21

Clinical Trial Update: Effect of Using Bitter Melon, Blueberries and Cranberries on HbA1c and Diabetes Symptom Levels [NA]

Completed clinical trial evaluating whether consuming bitter melon, blueberries, and cranberries affects HbA1c levels and diabetes symptoms …

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