Thrombotic Microangiopathy
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EMA guidance · 2026-07-15EMA Opinion under re-examination: Yartemlea (narsoplimab) — Omeros Ireland Limited
EMA opinion under re-examination for Yartemlea (narsoplimab) by Omeros Ireland Limited in therapeutic areas including Thrombotic Microangiop…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant [Phase 3]
A Phase 3 trial evaluating Ravulizumab for thrombotic microangiopathy after hematopoietic stem cell transplantation has completed.
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: TGD001 Treatment in Thrombotic Microangiopathies [Phase 1, Phase 2]
Clinical trial update for TGD001 in thrombotic microangiopathy and immune thrombocytopenia, currently not recruiting for Phase 1/Phase 2.
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura [NA]
A clinical trial evaluating immunosuppression, caplacizumab, and plasma infusion without therapeutic plasma exchange for immune-mediated thr…
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: Safety and Efficacy of Iptacopan in Patients With High-Risk Transplantation-Associated Thrombotic Microangiopathy [NA]
This clinical trial update states that iptacopan is being studied for high-risk transplantation-associated thrombotic microangiopathy and th…
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome [Phase 3]
A Phase 3 safety and efficacy trial of OMS721 in patients with atypical hemolytic uremic syndrome has been terminated, with results posted.
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
This clinical trial update reports a retrospective epidemiological study of patients in the national cohort of the French TMA Center, examin…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Complement Prospective Evaluation of Thrombotic Microangiopathy on Endothelium
This entry notes that a prospective study evaluating the role of complement-related thrombotic microangiopathy on the endothelium is current…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Identification of Plasma Biomarkers for Early Diagnosis of Transplant-associated Thrombotic Microangiopathy
This recruiting clinical study aims to identify plasma biomarkers for early diagnosis of transplant-associated thrombotic microangiopathy in…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Therapeutic Orientation Test in Thrombotic Microangiopathy [NA]
This entry reports a recruiting clinical study evaluating a Therapeutic Orientation Test for thrombotic microangiopathy.
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CLINICAL_TRIALS research · 2025-07-15Clinical Trial Update: TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients
The TRANSPIRE study is a longitudinal pediatric HSCT cohort investigating transplant-related lung injuries. It is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-14Clinical Trial Update: Thrombotic Microangiopathy (TMA) Associated With Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) In Adult Patients
A clinical trial is studying thrombotic microangiopathy associated with allogeneic hematopoietic stem cell transplantation in adult patients…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Nomacopan (rVA576) in Transplant Associated Thrombotic Microangiopathy [Phase 3]
Phase 3 trial of Nomacopan for transplant-associated thrombotic microangiopathy was terminated, with results posted.
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA [Phase 2]
Phase 2 pediatric study evaluating efficacy and safety of narsoplimab in high-risk hematopoietic stem cell transplantation–associated thromb…
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CLINICAL_TRIALS research · 2025-01-06Clinical Trial Update: Post-transplant Thrombotic Microangiopathy: Evaluation of Outcomes at the Bologna Kidney Transplant Centre
ClinicalTrials.gov update on a Bologna Kidney Transplant Centre study evaluating outcomes of post-transplant thrombotic microangiopathy in k…
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: Longitudinal Cohort of Thrombosis and Hemostasis Diseases
A longitudinal cohort clinical trial in China studying thrombosis and hemostasis diseases. It is currently recruiting at Peking University P…
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CLINICAL_TRIALS research · 2024-10-28Clinical Trial Update: Study to Evaluate Safety, Tolerability and Pharmacodynamics of KP104 in Participants With Thrombotic Microangiopathy Secondary to Systemic Lupus Erythematosus [Phase 2]
A Phase 2 clinical trial evaluating the safety, tolerability, and pharmacodynamics of KP104 in participants with thrombotic microangiopathy …
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Safety and Efficacy Study of OMS721 in Patients With Thrombotic Microangiopathies [Phase 2]
Phase 2 safety and efficacy study of OMS721 in thrombotic microangiopathies has completed. Results of the trial have been posted.
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CLINICAL_TRIALS trial_result · 2023-12-12Clinical Trial Update: Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger [Phase 3]
Phase 3 clinical trial evaluating ravulizumab for thrombotic microangiopathy associated with a trigger was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2023-01-27Clinical Trial Update: Multicenter, Uncontrolled Pilot Study Evaluating the Efficacy of Eculizumab in the Treatment of Gemcitabine-induced Thrombotic Microangiopathies [Phase 3]
Pilot multicenter trial evaluating eculizumab for gemcitabine-induced thrombotic microangiopathy; phase 3, status unknown.
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CLINICAL_TRIALS trial_result · 2023-01-04Clinical Trial Update: Ravulizumab and COVID-19 [Phase 3]
A Phase 3 clinical trial update for ravulizumab in COVID-19 and related thrombotic microangiopathy conditions; current status is unknown.
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CLINICAL_TRIALS trial_result · 2022-02-14Clinical Trial Update: A Safety and Efficacy Study of NAC in Patients With TA-TMA [Phase 3]
Phase 3 trial evaluating NAC for thrombotic microangiopathy shows completed status with posted results.
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CLINICAL_TRIALS trial_result · 2021-09-16Clinical Trial Update: Defibrotide TMA Prophylaxis Pilot Trial [Phase 2]
Phase 2 pilot trial evaluating defibrotide for prophylaxis of thrombotic microangiopathy has completed and results were posted.
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CLINICAL_TRIALS trial_result · 2018-03-30Clinical Trial Update: Identification and Treatment of Thrombotic Microangiopathies in Allogeneic Stem Cell Transplants
This completed clinical trial (NCT02604420) investigates approaches to identify and treat thrombotic microangiopathy following allogeneic st…
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CLINICAL_TRIALS trial_result · 2017-08-11Clinical Trial Update: Promising Bimarker Prediction of Outcome of HELLP Syndrome.
A completed clinical trial reports that certain biomarkers may predict outcomes in HELLP syndrome, potentially aiding prognosis in severe pr…