Squamous Cell Carcinoma of the Head and Neck
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Pilot Study of Imatinib Cetuximab Combo for H & N Cancer [EARLY_Phase 1]
A pilot early-phase trial evaluating the combination of imatinib and cetuximab for head and neck cancer; the study is currently active but n…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study to Test How BI 765063 and BI 770371 Are Taken up in Tumours of People With Different Types of Advanced Cancer Who Are Also Taking Ezabenlimab [Phase 1]
A Phase 1 clinical trial evaluating how BI 765063 and BI 770371 are taken up in tumors of patients with advanced cancers who are receiving e…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors [Phase 2]
Phase 2 clinical trial evaluating intraoperative imaging with indocyanine green for margin assessment in head and neck squamous cell carcino…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202 [Phase 2]
Phase 2 platform trial GALAXIES H&N-202 evaluating novel immunotherapy combinations as first-line treatment for PD-L1 positive recurrent/met…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial update for PF-08046052/SGN-EGFRd2 in advanced solid tumors, including colorectal cancer, non-small cell lung cancer, …
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy [NA]
A University of Virginia-sponsored clinical trial is recruiting to evaluate stereotactic MRI-guided focused ultrasound mesencephalotomy for …
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: A Study of DM005 in Patients With Advanced Solid Tumors [Phase 1]
DM005 is being studied in a Phase 1 trial for patients with advanced solid tumors, including non-small-cell lung cancer and head and neck sq…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy
A clinical trial update describing a multi-omic assessment of squamous cell cancers receiving systemic therapy; currently active but not rec…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: De-Escalation Surgery After Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 3]
A Phase 3 clinical trial is evaluating de-escalation surgery after immunotherapy for locally advanced head and neck squamous cell carcinoma …
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Multimodal Prediction of Response to Chemoradiotherapy for Squamous Cell Carcinoma of the Head and Neck [NA]
This clinical trial update describes a multimodal approach to predict response to chemoradiotherapy in squamous cell carcinoma of the head a…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies [Phase 1]
A Phase 1 study of JANX008 in advanced or metastatic solid tumors is currently recruiting, evaluating multiple indications including Non-Sma…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study [Phase 2]
This clinical trial update describes a Phase II randomized, double-blind study evaluating adjuvant pembrolizumab versus placebo in head and …
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction [Phase 1]
Phase 1 study evaluating the safety of a single administration of the AAV2hAQP1 gene therapy to the parotid gland in patients with irradiati…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Modi-1 Moditope in Breast, Head and Neck, Ovarian, or Renal Cancer [Phase 1, Phase 2]
Scancell's Modi-1 Moditope is being studied in Phase 1/2 trials across several cancers, including triple-negative breast cancer, renal cell …
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tumors [Phase 1]
Phase 1 trial update evaluating AB248 alone or with pembrolizumab in adults with solid tumors, including non-small cell lung cancer, melanom…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors [Phase 2]
A Phase 2 clinical trial by Iovance Biotherapeutics evaluating autologous tumor-infiltrating lymphocytes in solid tumors is currently recrui…
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CLINICAL_TRIALS research · 2025-06-06Clinical Trial Update: Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck [Phase 2]
This is a Phase 2 clinical trial update examining nivolumab in combination with BMS986205 for stage II-IV squamous cell cancers of the head …
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CLINICAL_TRIALS research · 2025-04-01Clinical Trial Update: Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients. [Phase 1, Phase 2]
Clinical trial update describing a Phase 1/2 study of TV5M01 for radiation-induced mucositis in head and neck cancer patients, with recruitm…
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CLINICAL_TRIALS research · 2025-02-26Clinical Trial Update: Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer [Phase 2]
This clinical trial update reports on a Phase 2 study evaluating cRGD-ZW800-1 for fluorescence-guided surgery in oral cancer, including head…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies [Phase 1, Phase 2]
This document reports a Phase 1/Phase 2 clinical trial evaluating GV20-0251 as monotherapy and in combination with pembrolizumab in several …
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck [Phase 2]
A Phase 2 clinical trial is evaluating preoperative immunotherapy in patients with squamous cell carcinoma of the head and neck. The study i…
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: Prognostic Counselling in Palliative Head and Neck Cancer (ProCoPall) [NA]
Active-not-recruiting clinical trial at Erasmus Medical Center studying prognostic counselling for patients with head and neck squamous cell…
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CLINICAL_TRIALS research · 2024-11-15Clinical Trial Update: Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067 [Phase 1, Phase 2]
Phase 1a/Phase 2 study evaluating safety, preliminary efficacy, PK and PD of ST-067 in various cancers; currently recruiting.
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CLINICAL_TRIALS research · 2024-09-20Clinical Trial Update: European Larynx Organ Preservation Study (ELOS) [MK-3475-C44] [Phase 2]
Phase 2 European Larynx Organ Preservation Study (ELOS) evaluates pembrolizumab (MK-3475) for organ-preserving treatment in squamous cell ca…
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CLINICAL_TRIALS research · 2024-08-02Clinical Trial Update: Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical Study [Phase 2]
Open-phase 2 multicenter trial evaluating Milaberon in advanced solid tumors across multiple indications, currently recruiting.