Spasticity
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Sign up freeTop drugs studied for this disease
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FDA approval · 2017-03-03FDA Approved: TIZANIDINE HYDROCHLORIDE — Original Application (Zydus Lifesciences Limited)
FDA approved the original application for a generic Tizanidine Hydrochloride from Zydus Lifesciences Limited.
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CLINICAL_TRIALS trial_result · 2017-02-03Clinical Trial Update: Efficacy and Safety Dose Titration Study of Botulinum Toxin Type A to Treat Spasticity in the Leg and Arm [Phase 3]
Phase 3 trial evaluating dose-titration of botulinum toxin type A for spasticity in the legs and arms due to cerebral causes. The study has …
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CLINICAL_TRIALS trial_result · 2017-01-26Clinical Trial Update: Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury [NA]
This update reports the completion of a clinical trial evaluating extracorporeal shock wave therapy (ESWT) as a treatment for spasticity in …
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CLINICAL_TRIALS trial_result · 2016-11-29Clinical Trial Update: Repeated Dose IV Baclofen Safety/Bioequivalence Study [Phase 1, Phase 2]
This document reports a Phase 1/2 study evaluating safety and bioequivalence of repeated-dose intravenous baclofen, sponsored by Allaysis, L…
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: The Effect of Extracorporeal Shock Wave Therapy on Spasticity [NA]
A completed clinical trial evaluated the effect of extracorporeal shock wave therapy on spasticity. The study status indicates the trial has…
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CLINICAL_TRIALS trial_result · 2016-03-03Clinical Trial Update: A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity [Phase 3]
A Phase III randomized trial comparing DWP450 to Botox for post-stroke upper limb spasticity has completed, evaluating safety and efficacy.
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CLINICAL_TRIALS trial_result · 2016-02-23Clinical Trial Update: Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation [NA]
A pilot study investigating the energy costs of spasticity in individuals with spinal cord injury has been terminated.
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CLINICAL_TRIALS trial_result · 2016-02-01Clinical Trial Update: BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity [Phase 3]
This Phase 3 trial update reports completion of a study evaluating BOTOX for post-stroke lower limb spasticity in adult patients, with resul…
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CLINICAL_TRIALS trial_result · 2016-01-26Clinical Trial Update: Reliability of an Algorithm to Diagnose Spasticity
Update on a completed clinical trial evaluating the reliability of an algorithm to diagnose spasticity.
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CLINICAL_TRIALS trial_result · 2016-01-26Clinical Trial Update: Prevalence of Spasticity in Veterans Living in a Long-term Care Facility
A completed Vanderbilt University clinical trial reports on the prevalence of spasticity among veterans living in a long-term care facility.
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CLINICAL_TRIALS trial_result · 2015-12-16Clinical Trial Update: Myobloc Atrophy Study [Phase 4]
Georgetown University reports completion of a Phase 4 study evaluating Myobloc (rimabotulinumtoxinB) for spasticity in patients with spinal …
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CLINICAL_TRIALS trial_result · 2015-11-05Clinical Trial Update: Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients [NA]
This completed trial evaluated early botulinum toxin type A injections to improve motor function and gait in stroke patients.
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CLINICAL_TRIALS trial_result · 2015-10-02Clinical Trial Update: Use of Ultrasound in Injections of Botulinum Toxin [NA]
A completed clinical trial evaluated ultrasound-guided injections of botulinum toxin for spasticity. The study was sponsored by University H…
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FDA approval · 2015-09-28FDA Approved: TIZANIDINE — Supplemental Application (Apotex Corp.)
FDA approved a supplemental application for tizanidine submitted by Apotex Corp.
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CLINICAL_TRIALS trial_result · 2015-08-18Clinical Trial Update: The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients [Phase 2]
Phase 2 clinical trial evaluating the effects of cannabis on spasticity and dystonia in pediatric patients; current status is unknown.
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CLINICAL_TRIALS research · 2015-06-03Clinical Trial Update: Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy [Phase 4]
This clinical trial update discusses a Phase 4 study evaluating functional electrical stimulation to improve gait in children with congenita…
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CLINICAL_TRIALS trial_result · 2015-06-01Clinical Trial Update: A Study to Define the ECG Effects of Tizanidine Compared to Placebo and the Positive Control, Moxifloxacin, in Healthy Men and Women Using a Blinded ECG Evaluator: A Thorough ECG Trial [Phase 2]
Phase 2 clinical trial evaluating ECG effects of tizanidine vs placebo and moxifloxacin in healthy adults; study completed with results post…
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CLINICAL_TRIALS trial_result · 2015-05-20Clinical Trial Update: Assessment and Management of Post-Stroke Spasticity With Botulinum Toxin-A [NA]
This clinical trial update reports the completed status of a study evaluating botulinum toxin type A for managing post-stroke spasticity.
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CLINICAL_TRIALS trial_result · 2015-05-04Clinical Trial Update: Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity [Phase 3]
A Phase III trial evaluating Botulax for post-stroke upper limb spasticity has completed.
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CLINICAL_TRIALS withdrawal · 2015-03-06Clinical Trial Update: Continuous Intrathecal Baclofen Infusion for Chronic Spasticity [Phase 3]
A Phase 3 trial evaluating continuous intrathecal baclofen infusion for chronic spasticity was withdrawn.
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FDA approval · 2015-02-11FDA Approved: GABLOFEN — Supplemental Application (Piramal Critical Care Inc)
FDA approved a supplemental application for GABLOFEN (baclofen injection) submitted by Piramal Critical Care Inc.
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CLINICAL_TRIALS trial_result · 2014-12-31Clinical Trial Update: Effects of DNHS Technique in the Treatment of Upper Limb Spasticity and Function in Stroke [NA]
This clinical trial evaluated the DNHS technique for upper-limb spasticity and function after stroke; the study is listed as completed, but …
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FDA approval · 2014-12-14FDA Approved: TIZANIDINE — Supplemental Application (Sun Pharmaceutical Industries, Inc.)
The FDA approved a supplemental application for a generic tizanidine product from Sun Pharmaceutical Industries under an ANDA. Tizanidine is…
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CLINICAL_TRIALS trial_result · 2014-11-18Clinical Trial Update: Early Use of Botulinum Toxin in Spasticity Post Stroke. [Phase 2]
Phase 2 trial results show early use of botulinum toxin to manage post-stroke spasticity; the study has completed.
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CLINICAL_TRIALS trial_result · 2014-09-10Clinical Trial Update: MDs on Botox Utility (MOBILITY)
A completed clinical trial evaluating Botox (onabotulinumtoxinA) for multiple movement disorders including blepharospasm, cervical dystonia …