Solid Tumors

• CLINICAL_TRIALS trial_result · 2025-04-09
  Clinical Trial Update: Safety and Tolerability Study for T-1101 (Tosylate) Capsules to Treat Advanced Refractory Solid Tumors [Phase 1]

  Phase 1 safety and tolerability study of T-1101 tosylate capsules for advanced solid tumors is currently active but not recruiting.

• CLINICAL_TRIALS research · 2025-04-09
  Clinical Trial Update: Phase Ib Trial of HS-20117 in Combination With Other Drugs in Advanced Solid Tumors [Phase 1]

  This document describes a Phase Ib trial of HS-20117 in combination with other drugs for advanced solid tumors, currently recruiting.

• CLINICAL_TRIALS research · 2025-04-08
  Clinical Trial Update: First-in-human Trial of PhOx430, a First-in-class Acetylglucosaminyltransferase V Inhibitor, in Advanced Solid Tumours [Phase 1]

  First-in-human Phase 1 trial of PhOx430, a first-in-class Acetylglucosaminyltransferase V inhibitor, assessed in advanced solid tumors; the …

• CLINICAL_TRIALS trial_result · 2025-04-08
  Clinical Trial Update: Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001) [Phase 1, Phase 2]

  Phase 1/2 study MK-1308-001 evaluating Quavonlimab in combination with Pembrolizumab in advanced solid tumors has completed. Results were po…

• CLINICAL_TRIALS research · 2025-04-08
  Clinical Trial Update: Granzyme B-targeted PET Imaging Monitoring Tumor Responses to Immunotherapy

  This clinical trial update describes a study using Granzyme B-targeted PET imaging to monitor tumor responses to immunotherapy, which is cur…

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• CLINICAL_TRIALS withdrawal · 2025-04-08
  Clinical Trial Update: A Study of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01B/LIGHTBEAM-U01) [Phase 1, Phase 2]

  A pediatric/young adult trial evaluating pembrolizumab with investigational agents for hematologic malignancies or solid tumors has been wit…

• CLINICAL_TRIALS trial_result · 2025-04-08
  Clinical Trial Update: Safety and Tolerability of Intravenous Administration of ICVB-1042 [Phase 1]

  Phase 1 safety and tolerability assessment of intravenous ICVB-1042 in patients with solid tumors has been terminated.

• CLINICAL_TRIALS trial_result · 2025-04-06
  Clinical Trial Update: Effect of Tusamitamab Ravtansine on QTc Interval in Participants With Metastatic Solid Tumors [Phase 1]

  Phase 1 trial assessing the effect of Tusamitamab Ravtansine on QTc interval in participants with metastatic solid tumors; the study has bee…

• CLINICAL_TRIALS research · 2025-04-02
  Clinical Trial Update: Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal

  Mayo Clinic is conducting a study to analyze blood and tumor tissue to identify diagnostic biomarkers in patients with metastatic cancer who…

• CLINICAL_TRIALS research · 2025-04-01
  Clinical Trial Update: A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2025 in Patients with Solid Tumors [Phase 1]

  A Phase 1 clinical study to evaluate the safety, tolerability, pharmacokinetics and biologic effect of VG2025 in patients with advanced mali…

• CLINICAL_TRIALS withdrawal · 2025-04-01
  Clinical Trial Update: A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors [Phase 1]

  A Phase 1 trial evaluating potential drug interactions between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in patients with advan…

• CLINICAL_TRIALS research · 2025-04-01
  Clinical Trial Update: Combination Therapy of Personalized mRNA-0217 Vaccines and Pembrolizumab in Patients With Advanced Solid Tumors [EARLY_Phase 1]

  A Phase 1 trial is evaluating a combination of a personalized mRNA-0217 vaccine with pembrolizumab in patients with advanced solid tumors an…

• CLINICAL_TRIALS research · 2025-03-26
  Clinical Trial Update: A Phase I Trial of Tumor-Associated Lymph Node T-Cell Injection With Advanced Malignant Solid Tumors [Phase 1]

  Phase I trial assessing Tumor-Associated Lymph Node T-Cell Injection alone or with Serplulimab for patients with advanced malignant solid tu…

• CLINICAL_TRIALS research · 2025-03-21
  Clinical Trial Update: Radiosurgery Before Surgery for the Treatment of Brain Metastases [EARLY_Phase 1]

  This document reports an early-phase clinical trial evaluating radiosurgery before surgery for brain metastases, with the study currently ac…

• CLINICAL_TRIALS research · 2025-03-20
  Clinical Trial Update: First-in-human Study of OT-A201 in Patients With Selected Hematological Malignancies and Solid Tumors [Phase 1]

  First-in-human Phase 1 trial evaluating OT-A201 in patients with selected hematologic malignancies and solid tumors; currently recruiting.

• CLINICAL_TRIALS trial_result · 2025-03-19
  Clinical Trial Update: Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors [Phase 1]

  Phase 1 trial of KT-333 in adults with refractory lymphomas and solid tumors reports safety, pharmacokinetics, pharmacodynamics, and prelimi…

• CLINICAL_TRIALS research · 2025-03-19
  Clinical Trial Update: A Phase I Study of LXP1788 Injection with Advanced Solid Tumors. [Phase 1]

  This Phase I trial is evaluating the safety and tolerability of LXP1788 Injection in adults with advanced solid tumors and is currently recr…

• CLINICAL_TRIALS research · 2025-03-19
  Clinical Trial Update: Clinical Trial of SYS6010±SYH2051 Versus Chemotherapy in Advanced Breast Cancer and Other Solid Tumors [Phase 1, Phase 2]

  Phase 1/2 clinical trial comparing SYS6010±SYH2051 versus chemotherapy in advanced breast cancer and other solid tumors; the study is not ye…

• CLINICAL_TRIALS trial_result · 2025-03-18
  Clinical Trial Update: A Study of BMS-986442 With Nivolumab With or Without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer [Phase 1, Phase 2]

  Phase 1/2 study of BMS-986442 with nivolumab, with or without chemotherapy, in solid tumors and non-small cell lung cancer has been terminat…

• CLINICAL_TRIALS trial_result · 2025-03-18
  Clinical Trial Update: EVM16 Injection As a Single and Combination with Tislelizumab in Solid Tumors [Phase 1]

  Phase 1 clinical trial evaluating EVM16 injection alone and in combination with tislelizumab in advanced or recurrent solid tumors; study is…

• CLINICAL_TRIALS trial_result · 2025-03-17
  Clinical Trial Update: Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid Tumors [Phase 1]

  Phase 1 clinical trial update of LP-284 in adults with relapsed or refractory lymphomas and advanced solid tumors, focusing on safety, pharm…

• CLINICAL_TRIALS trial_result · 2025-03-17
  Clinical Trial Update: A Phase 1/2 Study of VIO-01 in Participants With Recurrent Solid Tumors [Phase 1, Phase 2]

  Valerio Therapeutics terminated a Phase 1/2 trial of VIO-01 in patients with advanced or metastatic solid tumors, including breast, ovarian,…

• CLINICAL_TRIALS other · 2025-03-13
  Clinical Trial Update: A Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of MK-6204 (SKB535) for Injection in Participants With Advanced Solid Tumors [Phase 1]

  Phase 1 study to evaluate the safety, pharmacokinetics, and preliminary efficacy of MK-6204 (SKB535) for injection in participants with adva…

• CLINICAL_TRIALS trial_result · 2025-03-10
  Clinical Trial Update: A Study of AK112 for Advanced Solid Tumors [Phase 1, Phase 2]

  Clinical trial status update indicating that AK112's Phase 1/2 study in advanced solid tumors has been completed. The trial was sponsored by…

• CLINICAL_TRIALS research · 2025-03-05
  Clinical Trial Update: Supportive Care Needs of Former Child, AYA Cancer Patients, and of Their Parents: Evaluation During Long-term Follow-up

  This clinical trial update reports on evaluating the supportive care needs of former pediatric, adolescent and young adult cancer patients a…