Solid Tumors

• CLINICAL_TRIALS trial_result · 2025-12-24
  Clinical Trial Update: Randomized Phase II Study to Evaluate Efficacy of Web-based Patient-reported Outcome (PRO) Application in Solid Cancer Patients [NA]

  A randomized Phase II trial evaluating a web-based patient-reported outcome (PRO) application in patients with solid cancers has completed.

• CLINICAL_TRIALS research · 2025-12-24
  Clinical Trial Update: A Study of YL242 in Subjects With Advanced Solid Tumors [Phase 1, Phase 2]

  Phase 1/2 study of YL242 in advanced solid tumors is currently recruiting.

• CLINICAL_TRIALS trial_result · 2025-12-23
  Clinical Trial Update: Preclinical Safety Evaluation and First-in-Human Translational Study of [177Lu]Lu-TEFAPI-06 [EARLY_Phase 1]

  This update reports preclinical safety evaluation and the first-in-human translational study of [177Lu]Lu-TEFAPI-06 for metastatic solid tum…

• CLINICAL_TRIALS trial_result · 2025-12-23
  Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Efficacy and Indications of RP903 [Phase 1]

  Phase 1 study of RP903 conducted by Risen (Suzhou) Pharma Tech Co., Ltd. has completed, evaluating safety, tolerability, pharmacokinetics, e…

• CLINICAL_TRIALS research · 2025-12-23
  Clinical Trial Update: xDRIVE for Florida-based Cancer Patients [NA]

  A Florida-based clinical trial for a cancer therapy named xDRIVE is currently recruiting, sponsored by First Ascent Biomedical Inc.

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• CLINICAL_TRIALS trial_result · 2025-12-22
  Clinical Trial Update: A Study to Assess the Safety and Tolerability of RC88 for Patients With Advanced Solid Tumours [Phase 1, Phase 2]

  A completed Phase 1/Phase 2 study evaluating the safety and tolerability of RC88 in patients with solid tumors.

• CLINICAL_TRIALS research · 2025-12-22
  Clinical Trial Update: Study of TYK-01054 Capsules in Patients With Advanced Solid Tumors [Phase 1, Phase 2]

  A Phase 1/2 clinical trial evaluating TYK-01054 capsules in patients with advanced solid tumors, including malignant mesothelioma; the study…

• CLINICAL_TRIALS trial_result · 2025-12-22
  Clinical Trial Update: Clinical Trial of Rapamycin and Irinotecan in Pediatric Patients With Refractory Solid Tumors [Phase 1]

  Phase 1 trial evaluating the safety of combining rapamycin with irinotecan in pediatric patients with refractory solid tumors; the study has…

• CLINICAL_TRIALS research · 2025-12-19
  Clinical Trial Update: Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Solid Tumor Cancers With KRAS G12V Mutations [Phase 1]

  Phase 1 clinical trial evaluating autologous CD8+ and CD4+ T cells engineered with high-affinity KRASG12V-specific T cell receptors (FH-A11K…

• CLINICAL_TRIALS trial_result · 2025-12-19
  Clinical Trial Update: KZR-261 in Subjects With Advanced Solid Malignancies [Phase 1]

  A Phase 1 study of KZR-261 in subjects with advanced/metastatic solid tumors was terminated, and results have been posted.

• CLINICAL_TRIALS research · 2025-12-19
  Clinical Trial Update: A Clinical Study of GO306 in Patients With Advanced Solid Tumors [Phase 1]

  This document reports an ongoing Phase 1 study of GO306 in patients with advanced solid tumors. The trial is currently recruiting.

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC61in Subjects With Advanced Solid Tumors [Phase 1]

  This Phase 1 trial evaluated safety, tolerability, and pharmacokinetics/pharmacodynamics of ASC61 in adults with advanced solid tumors. The …

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: A Study of JNJ-64619178, an Inhibitor of PRMT5 in Participants With Advanced Solid Tumors, NHL, and Lower Risk MDS [Phase 1]

  Phase 1 study of JNJ-64619178, a PRMT5 inhibitor, in participants with advanced solid tumors, Non-Hodgkin Lymphoma, and lower-risk myelodysp…

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome [Phase 4]

  Phase 4 clinical trial update examining pegloticase for lowering uric acid in patients with tumor lysis syndrome; the study is active but no…

• CLINICAL_TRIALS research · 2025-12-18
  Clinical Trial Update: A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors [Phase 1]

  Phase 1 clinical trial evaluating PT0253 in participants with KRAS G12D-mutated advanced solid tumors; study is currently recruiting.

• CLINICAL_TRIALS research · 2025-12-18
  Clinical Trial Update: Educational Tools for the Improvement of Early Advance Care Planning in Adolescents and Young Adults With Advanced Solid Tumors and High-Grade Brain Tumors [NA]

  A Mayo Clinic-sponsored study is evaluating educational tools to improve early advance care planning in adolescents and young adults with ad…

• CLINICAL_TRIALS research · 2025-12-18
  Clinical Trial Update: A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors [Phase 1]

  A Phase 1 study to evaluate the safety of INCA33890 in participants with advanced or metastatic solid tumors is currently recruiting, sponso…

• CLINICAL_TRIALS trial_result · 2025-12-17
  Clinical Trial Update: Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors [Phase 1, Phase 2]

  This update reports the completion of a Phase 1/2 trial evaluating BMS-986315 alone and in combination with nivolumab or cetuximab in adults…

• CLINICAL_TRIALS research · 2025-12-17
  Clinical Trial Update: A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours) [Phase 1]

  A Phase 1 trial evaluating different doses of BI 1703880 in combination with Ezabenlimab to assess tolerability in adults with advanced soli…

• CLINICAL_TRIALS research · 2025-12-17
  Clinical Trial Update: Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors [Phase 1]

  Clinical trial update for a Phase 1 study evaluating the safety and pharmacokinetics of ADU-1805 in adults with advanced solid tumors; the s…

• CLINICAL_TRIALS research · 2025-12-17
  Clinical Trial Update: A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive [Phase 2]

  Clinical trial update for INCB099280 in Phase 2 evaluating patients with select solid tumors who have not previously received immune checkpo…

• CLINICAL_TRIALS research · 2025-12-16
  Clinical Trial Update: AT1019 Plus SBRT and PD-1 Inhibitor for Advanced Solid Tumors: An IIT Study [Phase 1]

  An Investigator Initiated Trial Phase 1 study is evaluating AT1019 in combination with SBRT and a PD-1 inhibitor for patients with advanced …

• CLINICAL_TRIALS trial_result · 2025-12-16
  Clinical Trial Update: RE002 T Cell Injection for the Treatment of KRAS G12D Mutated Solid Tumors [Phase 1]

  Phase 1 trial RE002 T cell injection is assessing safety and preliminary efficacy in KRAS G12D-mutated solid tumors; currently recruiting.

• CLINICAL_TRIALS research · 2025-12-16
  Clinical Trial Update: Community-Based Physical Activity Intervention for Underserved Cancer Survivors [NA]

  This clinical trial update describes a community-based physical activity intervention for underserved cancer survivors that is currently rec…

• CLINICAL_TRIALS research · 2025-12-16
  Clinical Trial Update: A Study of TIL in Advanced Solid Tumors (DFGD) [EARLY_Phase 1]

  An early Phase 1 trial evaluating tumor-infiltrating lymphocytes (TIL) therapy in patients with advanced solid tumors. Recruitment is ongoin…